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View Structure Prediction Details

Protein: YIM1
Organism: Saccharomyces cerevisiae
Length: 365 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YIM1.

Description E-value Query
Range		 Subject
Range
ADH3_GEOSE - Alcohol dehydrogenase OS=Geobacillus stearothermophilus PE=1 SV=1
 8.0E-83 [8..365] [1..337]
gi|7248741 - gi|7248741|gb|AAF43645.1|AF218309_1 alcohol dehydrogenase isozyme 3; Adh3 [Saccharomyces kluyveri]
 2.0E-79 [7..363] [31..370]
ADH3_KLULA - Alcohol dehydrogenase 3, mitochondrial OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70...
ADH3_KLULA - Alcohol dehydrogenase 3, mitochondrial OS=Kluyveromyces lactis GN=ADH3 PE=3 SV=2
 2.0E-78 [7..363] [32..371]
gi|2983768, gi|1... - gi|2983768|gb|AAC07327.1| alcohol dehydrogenase [Aquifex aeolicus VF5], gi|15606558|ref|NP_213938.1|...
gi|7427649 - pir||C70418 probable alcohol dehydrogenase (EC 1.1.1.-) - Aquifex aeolicus
 5.0E-78 [8..365] [1..343]
gi|171023 - gi|171023|gb|AAA34409.1| alcohol dehydrogenase III [Saccharomyces cerevisiae]
 1.0E-77 [5..363] [31..372]
gi|238878745 - gi|238878745|gb|EEQ42383.1| alcohol dehydrogenase II [Candida albicans WO-1]
ADH2_CANAL - Alcohol dehydrogenase 2 OS=Candida albicans GN=ADH2 PE=1 SV=1
ADH2_CANAL - Alcohol dehydrogenase 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADH2 PE=3 SV=1
 1.0E-77 [1..363] [1..345]

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Predicted Domain #1
Region A:
Residues: [1-131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEIVTNKS VTYVNNTTPV TITSSELDLR SCYQDDEVVI EVHAAALNPI DFITHQLCNS  60
   61 YIFGKYPKTY SRDYSGVIIK AGKDVDNRWK VGDKVNGMYS HIYGERGTLT HYLILNPAKD 120
  121 VPITHMVEVP K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.0
Match: 1hdyA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity 2.38343643417648 bayes_pls_golite062009
binding 2.29520443217747 bayes_pls_golite062009
protein binding 1.35579823286173 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.30535930879645 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 1.22416351603098 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.22202241547461 bayes_pls_golite062009
chaperone binding 1.19079350615542 bayes_pls_golite062009
DNA binding 1.02274180655721 bayes_pls_golite062009
transcription regulator activity 0.955628854752953 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.905392379451071 bayes_pls_golite062009
nucleic acid binding 0.901776352952123 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 0.861534636764975 bayes_pls_golite062009
transporter activity 0.793769336118517 bayes_pls_golite062009
structural molecule activity 0.75267483298133 bayes_pls_golite062009
ligase activity 0.742884668104576 bayes_pls_golite062009
transmembrane transporter activity 0.635891484075352 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.558610278939188 bayes_pls_golite062009
substrate-specific transporter activity 0.555188550031886 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.51503848775098 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.410307505174239 bayes_pls_golite062009
transcription factor activity 0.368443846770004 bayes_pls_golite062009
hydrolase activity 0.358696225508357 bayes_pls_golite062009
ion transmembrane transporter activity 0.29802814097478 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.261132005311306 bayes_pls_golite062009
active transmembrane transporter activity 0.239024094835991 bayes_pls_golite062009
catalytic activity 0.217171374336363 bayes_pls_golite062009
cation transmembrane transporter activity 0.212092278332619 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.113340150368917 bayes_pls_golite062009
pyrophosphatase activity 0.0696058100530442 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0591634687578807 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0560606007580392 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [132-151] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DENDPYDDFV YAAAWPLTFG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [302-365] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKKYNWRFGH PYPPNNFIEV GNEMIKKGTY KPPIDSVYEF DQYKEAIDRL MSNRAKGKVV  60
   61 VKMK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.0
Match: 1hdyA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [152-301] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAFSTLYDFK KDWTSDSKVL VIGASTSVSY AFVHIAKNYF NIGTVVGICS KNSIERNKKL  60
   61 GYDYLVPYDE GSIVENVKKL KQSVLENDKF DMIFDSVGNH DFFPVIDQFL KPKAKNSFYV 120
  121 TIAGNNKADY KNISWRDFVS LSSILKAINP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.0
Match: 1hdyA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle