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Protein Overview: SAS2

General Information:
Name(s) found: SAS2 / YMR127C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 338 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromatin [IDALink to PubMed article]
    nuclear chromosome, telomeric region [ICLink to PubMed article]
    Biological Process: chromatin silencing at telomere [IDALink to PubMed article]
    Molecular Function: acetyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARSLSQSLT ATTQKLKGKK NGGKGKNKPS AKIKKTQKEM LYGILNERNI RQIQFGLNKK  60
   61 FSTWYGSAVY FDPETKRLGC SETKGQLSSV SNSQYWLDTL FVCEYCFKYT DDQTRFVGHV 120
  121 ASCPFQYRVP GKIKYKSPEY TIRRVKGSKY QLFCQCLCLF TKLYLDNKSM YFKVDHYEFY 180
  181 IVYETGSTKP MGFFSKDLVS YQQNNLACIL IFPPYQRRGL GLLLIEFSYK LSQLEGVISG 240
  241 PEVPLSPFGL IGYLKYWSQI LCWHLIEGDL AHYDKVTLED LSIVTGMRVN DVILTLKHLN 300
  301 CIGENNQIYL QSLNSWLKLH GTKRNWFKLK DEYLLIDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SAS2 SAS4
    View Details Qiu et al. (2008) ARP4 SAS2 SAS3 SAS5 YNG1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SAS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 387.134302 Histone acetyltransferase ESA1
    2 View Details [124..236] PSI-BLAST 387.134302 Histone acetyltransferase ESA1
    3 View Details [237..338] PSI-BLAST 387.134302 Histone acetyltransferase ESA1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  10.330867741687 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  10.2385402730839 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  10.2385402730839 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  10.2097972775096 bayes_pls_golite062009
  • acetyltransferase activity
    		•  9.5414870492393 bayes_pls_golite062009
  • acyltransferase activity
    		•  8.84144467104026 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  8.80032457938662 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  8.58458341779614 bayes_pls_golite062009
    		• 7.30820970670781 bayes_pls_golite062009
    		• 5.06036596455843 bayes_pls_golite062009
  • transferase activity
    		•  2.87429355361226 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.24760844790231 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13750665291344 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.31507488567214 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.30526320413082 bayes_pls_golite062009
  • binding
    		•  1.22537494136129 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.2180007740195 bayes_pls_golite062009
  • transcription factor binding
    		•  1.13174003342838 bayes_pls_golite062009
  • transcription activator activity
    		•  0.891911076312861 bayes_pls_golite062009
  • glycylpeptide N-tetradecanoyltransferase activity
    		•  0.774009286200155 bayes_pls_golite062009
  • myristoyltransferase activity
    		•  0.774009286200155 bayes_pls_golite062009
  • H3 histone acetyltransferase activity
    		•  0.710926740598251 bayes_pls_golite062009
  • histone binding
    		•  0.582104626133107 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.31196049232138 bayes_pls_golite062009
  • protein binding
    		•  0.075825416385311 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle