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Protein Overview: CCS1

General Information:
Name(s) found: CCS1 / YMR038C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 249 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: intracellular copper ion transport [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: superoxide dismutase copper chaperone activity [IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTNDTYEAT YAIPMHCENC VNDIKACLKN VPGINSLNFD IEQQIMSVES SVAPSTIINT  60
   61 LRNCGKDAII RGAGKPNSSA VAILETFQKY TIDQKKDTAV RGLARIVQVG ENKTLFDITV 120
  121 NGVPEAGNYH ASIHEKGDVS KGVESTGKVW HKFDEPIECF NESDLGKNLY SGKTFLSAPL 180
  181 PTWQLIGRSF VISKSLNHPE NEPSSVKDYS FLGVIARSAG VWENNKQVCA CTGKTVWEER 240
  241 KDALANNIK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CCS1 SOD1
    View Details Krogan NJ, et al. (2006) CCS1 SOD1
    View Details Qiu et al. (2008) ATP6 ATP8 ATX1 CCS1 COX17 CTR2 MRS2 OLI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CCS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74]
    [220..249]    		 PSI-BLAST 1498.30103 Copper chaperone for superoxide dismutase, C-terminal domain; Copper chaperone for superoxide dismutase, N-terminal domain
    2 View Details [75..219] PSI-BLAST 1498.30103 Copper chaperone for superoxide dismutase, C-terminal domain; Copper chaperone for superoxide dismutase, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • superoxide dismutase activity
    		•  7.94023664290724 bayes_pls_golite062009
  • oxidoreductase activity, acting on superoxide radicals as acceptor
    		•  7.94023664290724 bayes_pls_golite062009
  • copper chaperone activity
    		•  6.14761367748172 bayes_pls_golite062009
  • metallochaperone activity
    		•  5.42894566783157 bayes_pls_golite062009
  • protein phosphatase 2B binding
    		•  5.27553309837204 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  5.18510514935825 bayes_pls_golite062009
  • copper-exporting ATPase activity
    		•  5.04749761961029 bayes_pls_golite062009
  • copper-transporting ATPase activity
    		•  5.03252922496602 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  4.79570221435856 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  4.53148536924187 bayes_pls_golite062009
  • copper-dependent protein binding
    		•  4.44884750959894 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.34070581398238 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.2525465295457 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.88287671106434 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.86202927496864 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  3.70964017127302 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  3.30291073809164 bayes_pls_golite062009
  • copper ion binding
    		•  3.29879077231683 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.27250923701445 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.98847682261773 bayes_pls_golite062009
  • binding
    		•  2.93936761631807 bayes_pls_golite062009
  • transition metal ion binding
    		•  2.79266255060927 bayes_pls_golite062009
  • transporter activity
    		•  2.43435890488191 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.32163502360862 bayes_pls_golite062009
  • protein phosphatase binding
    		•  2.23512886476996 bayes_pls_golite062009
  • metal ion binding
    		•  2.18824032052691 bayes_pls_golite062009
  • cation binding
    		•  2.18824032052691 bayes_pls_golite062009
  • ion binding
    		•  2.18098602266052 bayes_pls_golite062009
  • phosphatase binding
    		•  2.14114111316262 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.03363876969366 bayes_pls_golite062009
  • enzyme binding
    		•  1.82618630359051 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.53883152283038 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.39970933331095 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.39813577306223 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  1.38250427863906 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.38072038370649 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.38072038370649 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.37826353967694 bayes_pls_golite062009
  • protein binding
    		•  0.989113446856899 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.964982981309176 bayes_pls_golite062009
  • ATPase activity
    		•  0.948107394178372 bayes_pls_golite062009
  • hydrolase activity
    		•  0.930068054146566 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.903757171463128 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.887068390699274 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.884791447137788 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.835595471295029 bayes_pls_golite062009
  • chaperone binding
    		•  0.468633271737412 bayes_pls_golite062009
  • antioxidant activity
    		•  0.366710343827403 bayes_pls_golite062009
  • catalytic activity
    		•  0.270270255835869 bayes_pls_golite062009
  • zinc ion binding
    		•  0.25600715352161 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle