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View Structure Prediction Details

Protein: CCS1
Organism: Saccharomyces cerevisiae
Length: 249 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCS1.

Description E-value Query
Range
Subject
Range
CCS - copper chaperone for superoxide dismutase
1.0E-68 [8..245] [13..260]
CCS_RAT - Copper chaperone for superoxide dismutase OS=Rattus norvegicus GN=Ccs PE=1 SV=1
3.0E-66 [6..245] [11..260]
CCS_MOUSE - Copper chaperone for superoxide dismutase OS=Mus musculus GN=Ccs PE=1 SV=1
3.0E-66 [6..245] [11..260]
CCS1 - Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-...
gi|190408275 - gi|190408275|gb|EDV11540.1| copper chaperone [Saccharomyces cerevisiae RM11-1a]
CCS1_YEAST - Superoxide dismutase 1 copper chaperone OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
2.0E-57 [1..249] [1..249]
gi|25456033, gi|... - gi|3108347|gb|AAC15807.1| putative copper/zinc superoxide dismutase copper chaperone [Arabidopsis th...
1.0E-54 [9..238] [23..245]
gi|12963893 - gi|12963893|gb|AAK07691.1| Cu-chaperone for superoxide dismutase [Drosophila melanogaster]
2.0E-50 [5..245] [2..256]
gi|12711645 - gi|12711645|gb|AAK01931.1|AF329816_1 Cu/Zn-superoxide dismutase copper chaperone precursor [Glycine ...
2.0E-50 [9..238] [74..293]

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Predicted Domain #1
Region A:
Residues: [1-74]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTNDTYEAT YAIPMHCENC VNDIKACLKN VPGINSLNFD IEQQIMSVES SVAPSTIINT  60
   61 LRNCGKDAII RGAG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [220-249]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVWENNKQVC ACTGKTVWEE RKDALANNIK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1498.30103
Match: 1jk9B_
Description: Copper chaperone for superoxide dismutase, C-terminal domain; Copper chaperone for superoxide dismutase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
superoxide dismutase activity 7.94023664290724 bayes_pls_golite062009
oxidoreductase activity, acting on superoxide radicals as acceptor 7.94023664290724 bayes_pls_golite062009
copper chaperone activity 6.14761367748172 bayes_pls_golite062009
metallochaperone activity 5.42894566783157 bayes_pls_golite062009
protein phosphatase 2B binding 5.27553309837204 bayes_pls_golite062009
copper ion transmembrane transporter activity 5.18510514935825 bayes_pls_golite062009
copper-exporting ATPase activity 5.04749761961029 bayes_pls_golite062009
copper-transporting ATPase activity 5.03252922496602 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 4.79570221435856 bayes_pls_golite062009
metal ion transmembrane transporter activity 4.53148536924187 bayes_pls_golite062009
copper-dependent protein binding 4.44884750959894 bayes_pls_golite062009
cation transmembrane transporter activity 4.34070581398238 bayes_pls_golite062009
ion transmembrane transporter activity 4.2525465295457 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.88287671106434 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 3.86202927496864 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 3.70964017127302 bayes_pls_golite062009
superoxide dismutase copper chaperone activity 3.30291073809164 bayes_pls_golite062009
copper ion binding 3.29879077231683 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 3.27250923701445 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 2.98847682261773 bayes_pls_golite062009
binding 2.93936761631807 bayes_pls_golite062009
transition metal ion binding 2.79266255060927 bayes_pls_golite062009
transporter activity 2.43435890488191 bayes_pls_golite062009
transmembrane transporter activity 2.32163502360862 bayes_pls_golite062009
protein phosphatase binding 2.23512886476996 bayes_pls_golite062009
metal ion binding 2.18824032052691 bayes_pls_golite062009
cation binding 2.18824032052691 bayes_pls_golite062009
ion binding 2.18098602266052 bayes_pls_golite062009
phosphatase binding 2.14114111316262 bayes_pls_golite062009
substrate-specific transporter activity 2.03363876969366 bayes_pls_golite062009
enzyme binding 1.82618630359051 bayes_pls_golite062009
active transmembrane transporter activity 1.53883152283038 bayes_pls_golite062009
primary active transmembrane transporter activity 1.39970933331095 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 1.39813577306223 bayes_pls_golite062009
cation-transporting ATPase activity 1.38250427863906 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1.38072038370649 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 1.38072038370649 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 1.37826353967694 bayes_pls_golite062009
protein binding 0.989113446856899 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.964982981309176 bayes_pls_golite062009
ATPase activity 0.948107394178372 bayes_pls_golite062009
hydrolase activity 0.930068054146566 bayes_pls_golite062009
pyrophosphatase activity 0.903757171463128 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.887068390699274 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.884791447137788 bayes_pls_golite062009
ATPase activity, coupled 0.835595471295029 bayes_pls_golite062009
chaperone binding 0.468633271737412 bayes_pls_golite062009
antioxidant activity 0.366710343827403 bayes_pls_golite062009
catalytic activity 0.270270255835869 bayes_pls_golite062009
zinc ion binding 0.25600715352161 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [75-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPNSSAVAIL ETFQKYTIDQ KKDTAVRGLA RIVQVGENKT LFDITVNGVP EAGNYHASIH  60
   61 EKGDVSKGVE STGKVWHKFD EPIECFNESD LGKNLYSGKT FLSAPLPTWQ LIGRSFVISK 120
  121 SLNHPENEPS SVKDYSFLGV IARSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1498.30103
Match: 1jk9B_
Description: Copper chaperone for superoxide dismutase, C-terminal domain; Copper chaperone for superoxide dismutase, N-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle