Protein Overview: SEC65

General Information:
Name(s) found:	SEC65 / YML105C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|798895\|emb\|CAA89113.1\| Sec65p [Saccharomyces cerevisiae] [NCBI NR] gi\|671640\|emb\|CAA46666.1\| SEC65 [Saccharomyces cerevisiae] [NCBI NR] gi\|6323531\|ref\|NP_013602.1\| Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19; Sec65p [Saccharomyces cerevisiae] [NCBI NR] gi\|51013741\|gb\|AAT93164.1\| YML105C [Saccharomyces cerevisiae] [NCBI NR] gi\|266993\|sp\|P29478.1\|SEC65_YEAST RecName: Full=Signal recognition particle subunit SEC65 [NCBI NR] gi\|228680\|prf\|\|1808303A SEC65 gene [NCBI NR] pir\|\|S21731 signal recognition particle chain SEC65 - yeast (Saccharomyces cerevisiae) [NCBI NR] Signal recognition particle subunit SEC65 OS=Saccharomyces cerevisiae GN=SEC65 PE=1 SV=1 [Swiss-Prot] (P29478) Signal recognition particle SEC65 subunit [Swiss-Prot] SEC65 Signal recognition particle subunit [mips] Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 [SGD] SEC65, Chr XIII from 57866-58687, reverse complement [yeast_orfs2] Chr XIII from 57866-58687, reverse complement [yeastorf3.fasta] Chr XIII from 58687-57866, reverse complement [yeastorf5.fasta] SEC65 SGDID:S0004573, Chr XIII from 58687-57866, reverse complement, Verified ORF [yeastflysequest.fasta] Sec65p [Saccharomyces cerevisiae]gi\|51013741\|gb\|AAT93164.1\| YML105C [Saccharomyces cerevisiae]gi\|798895\|emb\|CAA89113.1\| Sec65p [Saccharomyces cerevisiae]gi\|671640\|emb\|CAA46666.1\| SEC65 [Saccharomyces cerevisiae]gi\|266993\|sp\|P29478\|SC65_YEAST Signal re [nrdb_11152004_Chlamydomonas] SEC65 SGDID:S000004573, Chr XIII from 58687-57866, reverse complement, Verified ORF, "Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Sec65p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SEC65 gene [nr-271106-contam.fasta] YML105C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SEC65 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19; Sec65p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Signal recognition particle subunit SEC65 [nr-271106-contam.fasta] [chemostatdb.fasta] Signal recognition particle subunit SEC65 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC65 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SEC65 SGDID:S000004573, Chr XIII from 58687-57866, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19" [yeast-030211-contam.fasta] SEC65 SGDID:S000004573, Chr XIII from 58687-57866, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19" [20141208_orf_trans.fasta] TR1726\|c0_g1_i1\|g.1251 ORF TR1726\|c0_g1_i1\|g.1251 TR1726\|c0_g1_i1\|m.1251 type:complete len:274 (+) TR1726\|c0_g1_i1:99-920(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR936\|c0_g1_i1\|g.617 ORF TR936\|c0_g1_i1\|g.617 TR936\|c0_g1_i1\|m.617 type:complete len:274 (+) TR936\|c0_g1_i1:101-922(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YML105C SGDID:S000004573, Chr XIII from 58687-57866, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_4141\|g.2772 ORF asmbl_4141\|g.2772 asmbl_4141\|m.2772 type:complete len:274 (+) asmbl_4141:101-922(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_4152\|g.2772 ORF asmbl_4152\|g.2772 asmbl_4152\|m.2772 type:complete len:274 (+) asmbl_4152:3698-4519(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_4143\|g.2779 ORF ID=asmbl_4143\|g.2779 ID=asmbl_4143\|m.2779 type:complete len:274 (+) ID=asmbl_4143:101-922(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_4153\|g.2727 ORF ID=asmbl_4153\|g.2727 ID=asmbl_4153\|m.2727 type:complete len:274 (+) ID=asmbl_4153:3700-4521(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	273 amino acids
Gene Ontology:
Cellular Component:	signal recognition particle, endoplasmic reticulum targeting [IDA][IMP][ISS]
Biological Process:	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [IMP] protein targeting to ER [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRLEEIDDF NDIDDLDMEL AELDPSLRTP IAPKITPKVV RSQDQENPAF LPGTNNNSNS  60
   61 NNNSSNEKEQ LSFINPKTGK VERSEAISKK DLEEVKRFQV LYPCYFDINR SHKEGRRVPK 120
  121 ELAVENPLAK TMADAVRELG ILCIFEGEKC HPQDFGNPGR IRVLFKENGQ LIGAATKFKG 180
  181 GKRQLMKAVG EYMKRHPTTI ESLREIPYGP DFDNIEFKKI PRVKGFKMNE IVPLHSPFLM 240
  241 GHPMTKSVYE TPKITAAEKS FKPPKNKYKV VRR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CSR1 LHP1 RPS0A SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
View Details	(MIPS) Mewes HW, et al. (2004)		SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
View Details	Krogan NJ, et al. (2006)		LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72 YCR090C
View Details	Gavin AC, et al. (2006)		SEC65 SRP14 SRP54 SRP68 SRP72
View Details	Gavin AC, et al. (2002)		BEM2 LHP1 SEC65 SRO9 SRP14 SRP21 SRP54 SRP68 SRP72
View Details	Qiu et al. (2008)		SEC65 SRP14 SRP21 SRP54 SRP68 SRP72

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NAF1	No Comments	Hazbun TR, et al. (2003)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SEC65	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..81]	deduced	N/A	No confident structure predictions are available.
2	View Details	[82..200]	PSI-BLAST	88.512579	SRP19
3	View Details	[201..273]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: SEC65

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: