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Protein Overview: LCB5

General Information:
Name(s) found: LCB5 / YLR260W [SGD]
Description(s) found:
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  • gi|74644938|sp|Q06147.1|LCB5_YEAST RecName: Full=Sphingoid long chain base kinase 5; Short=LCB kinase 5; AltName: Full=Sphinganine kinase 5 [NCBI NR]
  • gi|6323289|ref|NP_013361.1| Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; Lcb5p [Saccharomyc [NCBI NR]
  • gi|577178|gb|AAB67377.1| Ylr260wp [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S51398 hypothetical protein YLR260w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Sphingoid long chain base kinase 5 OS=Saccharomyces cerevisiae GN=LCB5 PE=1 SV=1 [Swiss-Prot]
  • LCB5 Sphingolipid long chain base kinase [mips]
  • Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules [SGD]
  • LCB5, Chr XII from 665844-667907 [yeast_orfs2]
  • Chr XII from 665844-667907 [yeastorf3.fasta]
  • >Q06147 (Q06147) Chromosome XII COSMID 8479 [4932.FASTACCERV.txt]
  • LCB5 SGDID:S0004250, Chr XII from 665846-667909, Verified ORF [yeastflysequest.fasta]
  • Lcb5p [Saccharomyces cerevisiae]gi|1077397|pir||S51398 hypothetical protein YLR260w - yeast (Saccharomyces cerevisiae)gi|577178|gb|AAB67377.1| Ylr260wp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • (Q06147) Ylr260wp [cerv4932.FASTAC]
  • LCB5 SGDID:S000004250, Chr XII from 665846-667909, Verified ORF, "Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as s [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; Lcb5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ylr260wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • LCB5 SGDID:S000004250, Chr XII from 665846-667909, Verified ORF, "Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Sphingoid long chain base kinase 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LCB5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • LCB5 SGDID:S000004250, Chr XII from 665844-667907, Genome Release 64-1-1, Verified ORF, "Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules" [yeast-030211-contam.fasta]
  • LCB5 SGDID:S000004250, Chr XII from 665844-667907, Genome Release 64-2-1, Verified ORF, "Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YLR260W SGDID:S000004250, Chr XII from 665844-667907, Genome Release 64-1-1, Verified ORF, "Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 687 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    soluble fraction [IDALink to PubMed article]
    Biological Process: response to heat [IDALink to PubMed article]
    calcium-mediated signaling [IMPLink to PubMed article]
    sphingolipid metabolic process [IDALink to PubMed article]
    Molecular Function: D-erythro-sphingosine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLKPSKRRK GRSRHSRKKQ ITSAILTEEG IMIKAKPSSP YTYANRMADK RSRSSIDNIS  60
   61 RTSFQSNISR TSFQSNSDNN SIFETASLIS CVTCLSDTDT IDRSETSTTD TSKDDLSANP 120
  121 KLHYPSVNGQ LPANTVIPYG RILDARYIEK EPLHYYDANS SPSSPLSSSM SNISEKCDLD 180
  181 ELESSQKKER KGNSLSRGSN SSSSLLTSRS PFTKLVEVIF ARPRRHDVVP KRVSLYIDYK 240
  241 PHSSSHLKEE DDLVEEILKR SYKNTRRNKS IFVIINPFGG KGKAKKLFMT KAKPLLLASR 300
  301 CSIEVVYTKY PGHAIEIARE MDIDKYDTIA CASGDGIPHE VINGLYQRPD HVKAFNNIAI 360
  361 TEIPCGSGNA MSVSCHWTNN PSYSTLCLIK SIETRIDLMC CSQPSYAREH PKLSFLSQTY 420
  421 GLIAETDINT EFIRWMGPAR FELGVAFNII QKKKYPCEIY VKYAAKSKNE LKNHYLEHKN 480
  481 KGSLEFQHIT MNKDNEDCDN YNYENEYETE NEDEDEDADA DDEDSHLISR DLADSSADQI 540
  541 KEEDFKIKYP LDEGIPSDWE RLDPNISNNL GIFYTGKMPY VAADTKFFPA ALPSDGTMDM 600
  601 VITDARTSLT RMAPILLGLD KGSHVLQPEV LHSKILAYKI IPKLGNGLFS VDGEKFPLEP 660
  661 LQVEIMPRLC KTLLRNGRYV DTDFDSM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) COP1 FCF2 FMP23 LCB5 PIP2 RET2 RET3 SCS2 SEC2 SEC21 SEC26 SEC27 SEC28
    View Details Qiu et al. (2008) LCB4 LCB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LCB5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..201] deduced N/A No confident structure predictions are available.
    2 View Details [202..412] Pfam 44.60206 Diacylglycerol kinase catalytic domain (presumed) No confident structure predictions are available.
    3 View Details [413..591] MSA 4.121989 View MSA. No confident structure predictions are available.
    4 View Details [592..687] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • kinase activity
    		•  0.697281815339077 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.541546416312833 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.416174911659548 bayes_pls_golite062009
  • catalytic activity
    		•  0.33446102778142 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle