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Protein Overview: YKE2

General Information:
Name(s) found: YKE2 / YLR200W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 114 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    prefoldin complex [IPILink to PubMed article][ISSLink to PubMed article]
    Biological Process: tubulin complex assembly [IMPLink to PubMed article][ISSLink to PubMed article]
    protein folding [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: tubulin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELGAKYQQ LQNELEEFIV ARQKLETQLQ ENKIVNEEFD QLEEDTPVYK LTGNVLLPVE  60
   61 QSEARTNVDK RLEFIETEIT RCEKNIRDKQ EELEKMRSEL IKLNNTAAST GPGR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GIM3 GIM4 GIM5 PAC10 PFD1 YKE2
    View Details (MIPS) Mewes HW, et al. (2004) GIM3 GIM4 GIM5 PAC10 YKE2
    View Details Krogan NJ, et al. (2006) GIM3 GIM4 GIM5 PAC10 PFD1 YKE2
    View Details Gavin AC, et al. (2006) GIM3 PAC10 YKE2
    View Details Gavin AC, et al. (2002) CDC48 GIM3 GIM5 PAC10 PFK1 SPC110 SPC97 SPC98 TUB4 YKE2
    View Details Qiu et al. (2008) GIM3 GIM4 GIM5 PAC10 YKE2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YKE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114] PSI-BLAST 6.0 Prefoldin beta subunit


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle