Protein Overview: SRN2

General Information:
Name(s) found:	SRN2 / YLR119W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6323148\|ref\|NP_013220.1\| Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus; Srn2p [Saccharomyces cerevisiae] [NCBI NR] gi\|2498956\|sp\|Q99176.1\|SRN2_YEAST RecName: Full=Protein SRN2; AltName: Full=Vacuolar protein sorting-associated protein 37; AltName: Full=ESCRT-I complex subunit VPS37 [NCBI NR] pir\|\|S64956 SRN2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1360520\|emb\|CAA97687.1\| SRN2 [Saccharomyces cerevisiae] [NCBI NR] gi\|1297034\|emb\|CAA61698.1\| L2958 [Saccharomyces cerevisiae] [NCBI NR] gi\|1256860\|gb\|AAB82366.1\| Srn2p [Saccharomyces cerevisiae] [NCBI NR] Protein SRN2 OS=Saccharomyces cerevisiae GN=SRN2 PE=1 SV=1 [Swiss-Prot] SRN2 Suppressor of rna1-1 mutation [mips] Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus [SGD] SRN2, Chr XII from 385535-386176 [yeast_orfs2] Chr XII from 385535-386176 [yeastorf3.fasta] (Q99176) SRN2 protein [4932.FASTACCERV.txt] SRN2 SGDID:S0004109, Chr XII from 385535-386176, Verified ORF [yeastflysequest.fasta] Srn2p [Saccharomyces cerevisiae]gi\|1297034\|emb\|CAA61698.1\| L2958 [Saccharomyces cerevisiae]gi\|1360520\|emb\|CAA97687.1\| SRN2 [Saccharomyces cerevisiae]gi\|2498956\|sp\|Q99176\|SRN2_YEAST SRN2 proteingi\|2133155\|pir\|\|S64956 SRN2 protein - yeast (Saccharomyces [nrdb_11152004_Chlamydomonas] SRN2 SGDID:S000004109, Chr XII from 385535-386176, Verified ORF, "Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] L2958 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SRN2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus; Srn2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Srn2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein SRN2 (Vacuolar protein sorting-associated protein 37) [nr-271106-contam.fasta] [chemostatdb.fasta] Protein SRN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRN2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SRN2 SGDID:S000004109, Chr XII from 385534-386175, Genome Release 64-1-1, Verified ORF, "Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus" [yeast-030211-contam.fasta] SRN2 SGDID:S000004109, Chr XII from 385534-386175, Genome Release 64-2-1, Verified ORF, "Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus" [20141208_orf_trans.fasta] YLR119W SGDID:S000004109, Chr XII from 385534-386175, Genome Release 64-1-1, Verified ORF, "Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	213 amino acids
Gene Ontology:
Cellular Component:	endosome [IPI] ESCRT I complex [IDA][IPI ]
Biological Process:	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IC] protein targeting to membrane [IMP][IPI] protein targeting to vacuole [IMP][IPI]
Molecular Function:	protein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVKATKLRI KQRRKNKGLN ISRLDIIRAE MDVVPSPGLP EKVNEKSKNI PLPEGINLLS  60
   61 SKEIIDLIQT HRHQLELYVT KFNPLTDFAG KIHAFRDQFK QLEENFEDLH EQKDKVQALL 120
  121 ENCRILESKY VASWQDYHSE FSKKYGDIAL KKKLEQNTKK LDEESSQLET TTRSIDSADD 180
  181 LDQFIKNYLD IRTQYHLRRE KLATWDKQGN LKY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		MVB12 RIM8 SRN2 STP22
View Details	Krogan NJ, et al. (2006)		MVB12 SRN2 STP22 VPS28
View Details	Qiu et al. (2008)		DID4 MVB12 SNF7 SNF8 SRN2 STP22 VPS20 VPS24 VPS28

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GBP2	SRN2	1	Unpublished Fields Lab Data
View Screen	RAD51	SRN2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..213]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2