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Protein Overview: SEN2

General Information:
Name(s) found: SEN2 / YLR105C [SGD]
Description(s) found:
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  • gi|6323134|ref|NP_013206.1| Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endon [NCBI NR]
  • pir||A38862 tRNA-splicing endonuclease beta chain - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|172576|gb|AAB65811.1| tRNA splicing endonuclease beta-subunit [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1360492|emb|CAA97670.1| SEN2 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|134427|sp|P16658.1|SEN2_YEAST RecName: Full=tRNA-splicing endonuclease subunit SEN2; AltName: Full=tRNA-intron endonuclease SEN2; AltName: Full=Splicing endonuclease protein 2 [NCBI NR]
  • gi|1256853|gb|AAB67547.1| Sen2p: tRNA-splicing endonuclease beta-subunit [Saccharomyces cerevisiae] [NCBI NR]
  • tRNA-splicing endonuclease subunit SEN2 OS=Saccharomyces cerevisiae GN=SEN2 PE=1 SV=1 [Swiss-Prot]
  • SEN2 tRNA splicing endonuclease beta subunit [mips]
  • Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease [SGD]
  • SEN2, Chr XII from 347048-348181, reverse complement [yeast_orfs2]
  • Chr XII from 347048-348181, reverse complement [yeastorf3.fasta]
  • Chr XII from 348181-347048, reverse complement [yeastorf5.fasta]
  • (P16658) tRNA-splicing endonuclease subunit SEN2 (EC 3.1.27.9) (tRNA-intron endonuclease) [4932.FASTACCERV.txt]
  • SEN2 SGDID:S0004095, Chr XII from 348181-347048, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Sen2p [Saccharomyces cerevisiae]gi|1360492|emb|CAA97670.1| SEN2 [Saccharomyces cerevisiae]gi|1256853|gb|AAB67547.1| Sen2p: tRNA-splicing endonuclease beta-subunit [Saccharomyces cerevisiae]gi|172576|gb|AAB65811.1| tRNA splicing endonuclease beta-subuni [nrdb_11152004_Chlamydomonas]
  • (P16658) tRNA-splicing endonuclease subunit SEN2 (EC 3.1.27.9) (tRNA-intron endonuclease SEN2) (Splicing endonuclease protein 2) [cerv4932.FASTAC]
  • SEN2 SGDID:S000004095, Chr XII from 348181-347048, reverse complement, Verified ORF, "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and ha [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SEN2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • tRNA-splicing endonuclease subunit SEN2 (tRNA-intron endonuclease SEN2) (Splicing endonuclease protein 2) [nr-271106-contam.fasta]
  • Sen2p: tRNA-splicing endonuclease beta-subunit [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • tRNA splicing endonuclease beta-subunit [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; Sen2p [Saccharomyce [nr-271106-contam.fasta]
  • SEN2 SGDID:S000004095, Chr XII from 348181-347048, reverse complement, Verified ORF, "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • tRNA-splicing endonuclease subunit SEN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEN2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SEN2 SGDID:S000004095, Chr XII from 348180-347047, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease" [yeast-030211-contam.fasta]
  • SEN2 SGDID:S000004095, Chr XII from 348180-347047, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease" [20141208_orf_trans.fasta]
  • YLR105C SGDID:S000004095, Chr XII from 348180-347047, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_8636|g.5248 ORF ID=asmbl_8636|g.5248 ID=asmbl_8636|m.5248 type:complete len:378 (+) ID=asmbl_8636:480-1613(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 377 amino acids

    Gene Ontology:
    Cellular Component: nuclear inner membrane [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    tRNA-intron endonuclease complex [TASLink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: tRNA splicing, via endonucleolytic cleavage and ligation [TASLink to PubMed article]
    Molecular Function: tRNA-intron endonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKGRVNQKR YKYPLPIHPV DDLPELILHN PLSWLYWAYR YYKSTNALND KVHVDFIGDT  60
   61 TLHITVQDDK QMLYLWNNGF FGTGQFSRSE PTWKARTEAR LGLNDTPLHN RGGTKSNTET 120
  121 EMTLEKVTQQ RRLQRLEFKK ERAKLERELL ELRKKGGHID EENILLEKQR ESLRKFKLKQ 180
  181 TEDVGIVAQQ QDISESNLRD EDNNLLDENG DLLPLESLEL MPVEAMFLTF ALPVLDISPA 240
  241 CLAGKLFQFD AKYKDIHSFV RSYVIYHHYR SHGWCVRSGI KFGCDYLLYK RGPPFQHAEF 300
  301 CVMGLDHDVS KDYTWYSSIA RVVGGAKKTF VLCYVERLIS EQEAIALWKS NNFTKLFNSF 360
  361 QVGEVLYKRW VPGRNRD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LOS1 SEN15 SEN2 SEN34 SEN54 STP1 STP2 STP3 STP4 TPT1 TRL1
    View Details Ho Y, et al. (2002) CCT2 CCT6 LAP4 LIA1 PEX7 SEC6 SEN2
    View Details Qiu et al. (2008) SEN15 SEN2 SEN34 SEN54 TRL1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SEN2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] MSA 1.015954 View MSA. No confident structure predictions are available.
    2 View Details [156..260] PSI-BLAST 67.529817 tRNA splicing endonuclease, C-terminal domain; tRNA splicing endonuclease EdnA, N-terminal domain
    3 View Details [261..377] PSI-BLAST 67.529817 tRNA splicing endonuclease, C-terminal domain; tRNA splicing endonuclease EdnA, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.47870548102815 bayes_pls_golite062009
  • protein binding
    		•  0.382621269105676 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle