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Protein Overview: CDC8

General Information:
Name(s) found: CDC8 / YJR057W [SGD]
Description(s) found:
Found 58 descriptions.
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  • Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 216 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: mutagenesis [IMPLink to PubMed articleLink to PubMed article]
    DNA repair [IMPLink to PubMed article]
    DNA-dependent DNA replication [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    dTDP biosynthetic process [IDALink to PubMed article]
    plasmid maintenance [IMPLink to PubMed article]
    dUDP biosynthetic process [IDALink to PubMed article]
    dTTP biosynthetic process [IDALink to PubMed article]
    Molecular Function: thymidylate kinase activity [IDALink to PubMed articleLink to PubMed article]
    uridylate kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMGRGKLILI EGLDRTGKTT QCNILYKKLQ PNCKLLKFPE RSTRIGGLIN EYLTDDSFQL  60
   61 SDQAIHLLFS ANRWEIVDKI KKDLLEGKNI VMDRYVYSGV AYSAAKGTNG MDLDWCLQPD 120
  121 VGLLKPDLTL FLSTQDVDNN AEKSGFGDER YETVKFQEKV KQTFMKLLDK EIRKGDESIT 180
  181 IVDVTNKGIQ EVEALIWQIV EPVLSTHIDH DKFSFF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CDC8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] PSI-BLAST 1257.0 Thymidylate kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  3.66392587433723 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.01286198424677 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  2.24094813695083 bayes_pls_golite062009
  • kinase activity
    		•  2.0779386406753 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.06460241490722 bayes_pls_golite062009
  • binding
    		•  2.05253348982328 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.0114051513686 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  1.96697952975573 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.92626167278464 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.9136419736217 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.6854386921174 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.64467072658718 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.5008821138859 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.49611313354225 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.748437190903548 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • adenylate kinase activity
    		•  0.447752711852745 bayes_pls_golite062009
  • CTP synthase activity
    		•  0.435702031552231 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.3625050107782 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.27925703205288 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.95561462330096E-4 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle