Protein Overview: CYC1

General Information:
Name(s) found:	CYC1 / YJR048W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|695795\|gb\|AAA62856.1\| iso-1-cytochrome c [Saccharomyces cerevisiae] [NCBI NR] pir\|\|CCBY cytochrome c 1 [validated] - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6322508\|ref\|NP_012582.1\| Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; Cyc1p [Saccharomyces c [NCBI NR] gi\|3627\|emb\|CAA24605.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|226065\|prf\|\|1409323A CYC1 locus [NCBI NR] gi\|171258\|gb\|AAB59344.1\| iso-1-cytochrome c [Saccharomyces cerevisiae] [NCBI NR] gi\|1197077\|gb\|AAA88751.1\| ORF; putative [Saccharomyces cerevisiae] [NCBI NR] gi\|117901\|sp\|P00044.2\|CYC1_YEAST RecName: Full=Cytochrome c iso-1 [NCBI NR] gi\|1015707\|emb\|CAA89576.1\| CYC1 [Saccharomyces cerevisiae] [NCBI NR] Cytochrome c iso-1 OS=Saccharomyces cerevisiae GN=CYC1 PE=1 SV=2 [Swiss-Prot] CYC1 Cytochrome-c isoform 1 [mips] Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration [SGD] CYC1, Chr X from 526027-526356 [yeast_orfs2] Chr X from 526027-526356 [yeastorf3.fasta] Chr X from 526028-526357 [yeastorf4.fasta] Chr X from 526029-526358 [yeastorf5.fasta] CYC1 SGDID:S0003809, Chr X from 526249-526578, Verified ORF [yeastflysequest.fasta] Cyc1p [Saccharomyces cerevisiae]gi\|3627\|emb\|CAA24605.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1015707\|emb\|CAA89576.1\| CYC1 [Saccharomyces cerevisiae]gi\|65488\|pir\|\|CCBY cytochrome c 1 [validated] - yeast (Saccharomyces cerevisiae)gi\|1712 [nrdb_11152004_Chlamydomonas] CYC1 SGDID:S000003809, Chr X from 526249-526578, Verified ORF, "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CYC1 SGDID:S000003809, Chr X from 526328-526657, Verified ORF, "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular [yeast-contam.fasta] CYC1 SGDID:S000003809, Chr X from 526327-526656, Verified ORF, "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular [yeast-200209-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Cytochrome c iso-1 [nr-271106-contam.fasta] iso-1-cytochrome c [nr-271106-contam.fasta] CYC1 locus [nr-271106-contam.fasta] CYC1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ORF; putative [nr-271106-contam.fasta] Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; Cyc1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CYC1 SGDID:S000003809, Chr X from 526327-526656, Verified ORF, "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration" [yeast-bovrabprots.fasta] CYC1 SGDID:S000003809, Chr X from 526328-526657, Verified ORF, "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration" [yeast-contam_custom.fasta] [chemostatdb.fasta] Cytochrome c iso-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYC1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CYC1 SGDID:S000003809, Chr X from 526335-526664, Genome Release 64-1-1, Verified ORF, "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration" [yeast-030211-contam.fasta] CYC1 SGDID:S000003809, Chr X from 526335-526664, Genome Release 64-2-1, Verified ORF, "Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; mutations in human homolog cause insulin-responsive hyperglycemia; CYC1 has a paralog, CYC7, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YJR048W SGDID:S000003809, Chr X from 526335-526664, Genome Release 64-1-1, Verified ORF, "Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_5693\|g.3905 ORF asmbl_5693\|g.3905 asmbl_5693\|m.3905 type:complete len:110 (+) asmbl_5693:128-457(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_5696\|g.3430 ORF ID=asmbl_5696\|g.3430 ID=asmbl_5696\|m.3430 type:complete len:110 (+) ID=asmbl_5696:128-457(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	109 amino acids
Gene Ontology:
Cellular Component:	mitochondrial intermembrane space [IDA] mitochondrion [IDA]
Biological Process:	electron transport [TAS]
Molecular Function:	electron carrier activity [TAS]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MTEFKAGSAK KGATLFKTRC LQCHTVEKGG PHKVGPNLHG IFGRHSGQAE GYSYTDANIK 60 61 KNVLWDENNM SEYLTNPKKY IPGTKMAFGG LKKEKDRNDL ITYLKKACE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		COB COX1 COX2 COX3 COX4 COX8 CYB2 CYC1 CYC7 CYT1 MCR1 QCR2 QCR9 RIP1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CYC1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..109]	PSI-BLAST	589.980454	Mitochondrial cytochrome c

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	7.77694826742571	bayes_pls_golite062009
ubiquinol-cytochrome-c reductase activity	7.77694826742571	bayes_pls_golite062009
electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	5.3228546115966	bayes_pls_golite062009
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity	4.97969104367667	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	4.83198573144889	bayes_pls_golite062009
oxidoreductase activity	4.80453374142732	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	4.69221581420605	bayes_pls_golite062009
electron carrier activity	4.50051625202265	bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors	4.39250939893637	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	4.11195915185456	bayes_pls_golite062009
phosphoprotein phosphatase activity	3.07137767450073	bayes_pls_golite062009
protein serine/threonine phosphatase activity	3.05900853572871	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	2.75675744166378	bayes_pls_golite062009
peroxidase activity	2.75675744166378	bayes_pls_golite062009
antioxidant activity	2.60087791856484	bayes_pls_golite062009
phosphatase activity	2.58257339159796	bayes_pls_golite062009
phosphoric ester hydrolase activity	2.48742191899955	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.67966224915812	bayes_pls_golite062009
binding	1.60003804759784	bayes_pls_golite062009
transporter activity	1.44083733311658	bayes_pls_golite062009
protein binding	1.33090393131805	bayes_pls_golite062009
transmembrane transporter activity	1.28161778948702	bayes_pls_golite062009
substrate-specific transporter activity	1.15573917988688	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.01443199299167	bayes_pls_golite062009
ion transmembrane transporter activity	0.881486298760893	bayes_pls_golite062009
cation transmembrane transporter activity	0.783993292151034	bayes_pls_golite062009
hydrolase activity	0.624991704964657	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle