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Protein Overview: GEF1

General Information:
Name(s) found: GEF1 / YJR040W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 779 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    Golgi-associated vesicle [TASLink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IMPLink to PubMed article]
    cellular copper ion homeostasis [IMPLink to PubMed article]
    cellular cation homeostasis [TASLink to PubMed article]
    Molecular Function: voltage-gated chloride channel activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTTYVPINQ PIGDGEDVID TNRFTNIPET QNFDQFVTID KIAEENRPLS VDSDREFLNS  60
   61 KYRHYREVIW DRAKTFITLS STAIVIGCIA GFLQVFTETL VNWKTGHCQR NWLLNKSFCC 120
  121 NGVVNEVTST SNLLLKRQEF ECEAQGLWIA WKGHVSPFII FMLLSVLFAL ISTLLVKYVA 180
  181 PMATGSGISE IKVWVSGFEY NKEFLGFLTL VIKSVALPLA ISSGLSVGKE GPSVHYATCC 240
  241 GYLLTKWLLR DTLTYSSQYE YITAASGAGV AVAFGAPIGG VLFGLEEIAS ANRFNSSTLW 300
  301 KSYYVALVAI TTLKYIDPFR NGRVILFNVT YDRDWKVQEI PIFIALGIFG GLYGKYISKW 360
  361 NINFIHFRKM YLSSWPVQEV LFLATLTALI SYFNEFLKLD MTESMGILFH ECVKNDNTST 420
  421 FSHRLCQLDE NTHAFEFLKI FTSLCFATVI RALLVVVSYG ARVPAGIFVP SMAVGATFGR 480
  481 AVSLLVERFI SGPSVITPGA YAFLGAAATL SGITNLTLTV VVIMFELTGA FMYIIPLMIV 540
  541 VAITRIILST SGISGGIADQ MIMVNGFPYL EDEQDEEEEE TLEKYTAEQL MSSKLITINE 600
  601 TIYLSELESL LYDSASEYSV HGFPITKDED KFEKEKRCIG YVLKRHLASK IMMQSVNSTK 660
  661 AQTTLVYFNK SNEELGHREN CIGFKDIMNE SPISVKKAVP VTLLFRMFKE LGCKTIIVEE 720
  721 SGILKGLVTA KDILRFKRIK YREVHGAKFT YNEALDRRCW SVIHFIIKRF TTNRNGNVI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ATX2 GEF1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97]
    [189..209]
    [232..325]    		 PSI-BLAST 224.221849 Clc chloride channel
    2 View Details [98..188]
    [210..231]
    [326..571]    		 PSI-BLAST 224.221849 Clc chloride channel
    3 View Details [572..779] PSI-BLAST 27.154902 Inosine monophosphate dehydrogenase (IMPDH)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • anion channel activity
    		•  6.77290758049983 bayes_pls_golite062009
  • chloride channel activity
    		•  6.77290758049983 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  6.08111514985329 bayes_pls_golite062009
  • voltage-gated chloride channel activity
    		•  5.99544422864122 bayes_pls_golite062009
  • voltage-gated anion channel activity
    		•  5.99544422864122 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.07840957725271 bayes_pls_golite062009
  • ion channel activity
    		•  4.93164650815682 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  4.81149777353187 bayes_pls_golite062009
  • channel activity
    		•  4.78965126968592 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  4.78965126968592 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.67227438984104 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.27956097534048 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.255638017629 bayes_pls_golite062009
  • gated channel activity
    		•  4.1072949331811 bayes_pls_golite062009
  • transporter activity
    		•  2.94995161862691 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.84443650880263 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.82470397063503 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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