Protein Overview: AIR1

General Information:
Name(s) found:	AIR1 / YIL079C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731833\|sp\|P40507.1\|AIR1_YEAST RecName: Full=Protein AIR1; AltName: Full=Arginine methyltransferase-interacting RING finger protein 1 [NCBI NR] gi\|6322111\|ref\|NP_012186.1\| RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p; Air1p [Saccharomyces cerevisi [NCBI NR] pir\|\|S48365 hypothetical protein YIL079c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|556868\|emb\|CAA86091.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P40507) Hypothetical 41.6 kDa protein in SDS3-THS1 intergenic region [Swiss-Prot] Protein AIR1 OS=Saccharomyces cerevisiae GN=AIR1 PE=1 SV=1 [Swiss-Prot] AIR1 Arginine methyltransferase-interacting RING finger protein [mips] Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p [SGD] YIL079C, Chr IX from 210920-212002, reverse complement [yeast_orfs2] Chr IX from 210920-212002, reverse complement [yeastorf3.fasta] Chr IX from 212002-210920, reverse complement [yeastorf5.fasta] AIR1 SGDID:S0001341, Chr IX from 212002-210920, reverse complement, Verified ORF [yeastflysequest.fasta] Air1p [Saccharomyces cerevisiae]gi\|556868\|emb\|CAA86091.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|731833\|sp\|P40507\|YIH9_YEAST Hypothetical 41.6 kDa protein in SDS3-THS1 intergenic regiongi\|626297\|pir\|\|S48365 hypothetical protein YIL079c - [nrdb_11152004_Chlamydomonas] AIR1 SGDID:S000001341, Chr IX from 212002-210920, reverse complement, Verified ORF, "RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and expor [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein AIR1 (Arginine methyltransferase-interacting RING finger protein 1) [nr-271106-contam.fasta] RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p; Air1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] AIR1 SGDID:S000001341, Chr IX from 212002-210920, reverse complement, Verified ORF, "Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] AIR1 SGDID:S000001341, Chr IX from 212002-210920, reverse complement, Verified ORF, "RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] AIR1 SGDID:S000001341, Chr IX from 212002-210920, reverse complement, Verified ORF, "Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p" [SGDyeast.20101221.fasta] Protein AIR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AIR1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] AIR1 SGDID:S000001341, Chr IX from 212005-210923, Genome Release 64-1-1, reverse complement, Verified ORF, "Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p" [yeast-030211-contam.fasta] AIR1 SGDID:S000001341, Chr IX from 212005-210923, Genome Release 64-2-1, reverse complement, Verified ORF, "Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome" [20141208_orf_trans.fasta] TR6311\|c0_g1_i1\|g.4459 ORF TR6311\|c0_g1_i1\|g.4459 TR6311\|c0_g1_i1\|m.4459 type:complete len:361 (+) TR6311\|c0_g1_i1:222-1304(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YIL079C SGDID:S000001341, Chr IX from 212005-210923, Genome Release 64-1-1, reverse complement, Verified ORF, "Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_8773\|g.6402 ORF asmbl_8773\|g.6402 asmbl_8773\|m.6402 type:complete len:361 (+) asmbl_8773:222-1304(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_8779\|g.5407 ORF ID=asmbl_8779\|g.5407 ID=asmbl_8779\|m.5407 type:complete len:361 (+) ID=asmbl_8779:222-1304(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	360 amino acids
Gene Ontology:
Cellular Component:	nucleus [IPI] nucleolus [IDA] TRAMP complex [IDA][IPI ]
Biological Process:	mRNA export from nucleus [IMP] rRNA catabolic process [IGI] snRNA catabolic process [IGI] snoRNA catabolic process [IGI] tRNA catabolic process [IDA] ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process [IDA][IGI]
Molecular Function:	polynucleotide adenylyltransferase activity [IDA ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLLSEVES IDTLPYVKDT TPTGSDSSSF NKLLAPSIED VDANPEELRT LRGQGRYFGI  60
   61 TDYDSNGAIM EAEPKCNNCS QRGHLKRNCP HVICTYCGFM DDHYSQHCPK AIICTNCNAN 120
  121 GHYKSQCPHK WKKVFCTLCN SKRHSRERCP SIWRSYLLKT KDANQGDFDF QTVFCYNCGN 180
  181 AGHFGDDCAE RRSSRVPNTD GSAFCGDNLA TKFKQHYFNQ LKDYKREASQ RQHFDNEHEF 240
  241 NLLDYEYNDD AYDLPGSRTY RDKMKWKGKV QSTRNKNSSN NRYESSNNRK KKSPFSAQNY 300
  301 KVTKNKRVQT HPLDFPRSSQ NNRTNDYSSQ FSYNRDDFPK GPKNKRGRSS SNKSQRNGRY 360
  361

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		AIR1 MTR4 PAP2
View Details	Krogan NJ, et al. (2006)		AIR1 AIR2 MTR4 PAP2 PSO2 RPL18A, RPL18B STE4 TRF5
View Details	Ho Y, et al. (2002)		AIR1 AIR2 DED1 HRB1 IMD1 IMD3 IMD4 MTR4 NAP1 NOP53 NOP56 NPL3 PAP2 PSE1
View Details	Qiu et al. (2008)		AIR1 AIR2 DBP7 DRS1 MTR4 NOG2 NOP1 NOP2 PAP2 RNT1 RRP3 TRF5

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	IMP4	AIR1	2	Unpublished Fields Lab Data
View Screen	CDC24	AIR1	2	Drees BL, et al. (2001)
View Screen	SKY1	AIR1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	AIR1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..99]	PSI-BLAST	35.522879	HIV capsid protein, dimerisation domain
2	View Details	[100..168]	PSI-BLAST	24.69897	HIV nucleocapsid
3	View Details	[169..233]	deduced	N/A	No confident structure predictions are available.
4	View Details	[234..360]	MSA	25.029993	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transcription regulator activity	3.04588712677166	bayes_pls_golite062009
DNA binding	2.53317408686316	bayes_pls_golite062009
nucleic acid binding	2.33828046499668	bayes_pls_golite062009
binding	2.07015157850093	bayes_pls_golite062009
transcription factor activity	2.0090791129794	bayes_pls_golite062009
transcription activator activity	0.68790059848359	bayes_pls_golite062009
protein binding	0.679430693038119	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2