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Protein Overview: YGR283C

General Information:
Name(s) found: YGR283C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein of unknown function; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 341 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVKHKSESL KHEEGAAKKA KTGLLKLKKI MDIESNVVKY SICIPTTVID NCNNLEQVTF  60
   61 TAYQIARTAV LFNVQEIIVL DQSKDKKHEK KSRSKETISD CLLLATLLQY FVTPPNLLDT 120
  121 TFKKKNKLYL KCASTFPPLN QLPFMNASAE QHYKEGLSIA RDSSKGKSDD ALTNLVYIGK 180
  181 NQIITLSNQN IPNTARVTVD TERKEVVSPI DAYKGKPLGY HVRMASTLNE VSEGYTKIVW 240
  241 VNSGDFHYDE ELSKYHKVET KLPYIAKLKK SSTSEKPCNI LLIFGKWGHL KRCFRRSDLE 300
  301 SSSLHHYFSG QLQFPASVPQ GNIPIQDSLP IALTMFQRWA S

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GAR1 NHP2 YGR283C YMR310C
    View Details Krogan NJ, et al. (2006) SAN1 YGR283C YMR310C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TOS3 YGR283C 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YGR283C Huh WK, et al. (2003)
    View Data YGR283C and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110]
    [218..341]    		 PSI-BLAST 47.39794 Hypothetical protein MTH1 (MT0001), insert domain; Hypothetical protein MTH1 (MT0001), dimerisation domain
    2 View Details [111..217] PSI-BLAST 47.39794 Hypothetical protein MTH1 (MT0001), insert domain; Hypothetical protein MTH1 (MT0001), dimerisation domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of ribosome
    		•  6.10995066483033 bayes_pls_golite062009
  • structural molecule activity
    		•  5.55926301079047 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.05692269334609 bayes_pls_golite062009
  • methyltransferase activity
    		•  1.82347727012845 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  1.75463745431819 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  1.28709139538479 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.27646201386283 bayes_pls_golite062009
  • RNA binding
    		•  1.26793351043713 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.22883489365565 bayes_pls_golite062009
  • DNA binding
    		•  1.03854786806734 bayes_pls_golite062009
  • binding
    		•  1.0385094021694 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.03810655279652 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.02104056959293 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.991198550579488 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.98640864840845 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.707861773634749 bayes_pls_golite062009
    		• 0.596347353533061 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.567929700499153 bayes_pls_golite062009
  • transferase activity
    		•  0.269890329731988 bayes_pls_golite062009
  • catalytic activity
    		•  0.254696427664799 bayes_pls_golite062009
  • protein binding
    		•  0.0494791880947549 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle