YRC Public Data Repository - Protein Structure Prediction

Protein:	YGR283C
Organism:	Saccharomyces cerevisiae
Length:	341 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGR283C.

Description	E-value	Query Range	Subject Range
YG5X_YEAST - Putative methyltransferase YGR283C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGR28... YGR283C - Protein of unknown function; may interact with ribosomes, based on co-purification experiments; pred...	0.0	[1..341]	[1..341]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..337]	[62..378]
CG12128-PA - This gene is referred to in FlyBase by the symbol Dmel\CG12128 (CG12128, FBgn0033473). It is a prote...	2.0E-82	[1..327]	[33..361]
YGWG_SCHPO - Putative methyltransferase SPBC8D2.16c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pi0... SPBC8D2.16c - DUF171 family protein	5.0E-57	[33..264]	[11..253]
gi\|18314060, gi\|... - gi\|18314060\|ref\|NP_560727.1\| hypothetical protein PAE3431 [Pyrobaculum aerophilum str. IM2], gi\|1816...	3.0E-52	[40..336]	[2..257]
gi\|5457775, gi\|7... - pir\|\|B75148 hypothetical protein PAB2119 - Pyrococcus abyssi (strain Orsay), gi\|5457775\|emb\|CAB49265... gi\|5457775, gi\|1... - gi\|5457775\|emb\|CAB49265.1\| Hypothetical protein [Pyrococcus abyssi GE5], gi\|14520559\|ref\|NP_126034.1...	4.0E-50	[42..336]	[5..252]
gi\|7429565 - pir\|\|B71188 hypothetical protein PH1779 - Pyrococcus horikoshii gi\|14591536, gi\|... - gi\|3258214\|dbj\|BAA30897.1\| 258aa long hypothetical protein [Pyrococcus horikoshii OT3], gi\|14591536\|...	3.0E-49	[42..336]	[5..252]
gi\|18978198, gi\|... - gi\|18978198\|ref\|NP_579555.1\| hypothetical protein PF1826 [Pyrococcus furiosus DSM 3638], gi\|18894007...	7.0E-49	[42..336]	[5..252]

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Predicted Domain #1

Region A:
Residues: [1-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVKHKSESL KHEEGAAKKA KTGLLKLKKI MDIESNVVKY SICIPTTVID NCNNLEQVTF  60
   61 TAYQIARTAV LFNVQEIIVL DQSKDKKHEK KSRSKETISD CLLLATLLQY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [218-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGYHVRMAST LNEVSEGYTK IVWVNSGDFH YDEELSKYHK VETKLPYIAK LKKSSTSEKP  60
   61 CNILLIFGKW GHLKRCFRRS DLESSSLHHY FSGQLQFPAS VPQGNIPIQD SLPIALTMFQ 120
  121 RWAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.39794
Match:	1k3rA_
Description:	Hypothetical protein MTH1 (MT0001), insert domain; Hypothetical protein MTH1 (MT0001), dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of ribosome	6.10995066483033	bayes_pls_golite062009
structural molecule activity	5.55926301079047	bayes_pls_golite062009
RNA methyltransferase activity	3.05692269334609	bayes_pls_golite062009
methyltransferase activity	1.82347727012845	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.75463745431819	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	1.28709139538479	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	1.27646201386283	bayes_pls_golite062009
RNA binding	1.26793351043713	bayes_pls_golite062009
exoribonuclease activity	1.22883489365565	bayes_pls_golite062009
DNA binding	1.03854786806734	bayes_pls_golite062009
binding	1.0385094021694	bayes_pls_golite062009
3'-5' exonuclease activity	1.03810655279652	bayes_pls_golite062009
ribonuclease activity	1.02104056959293	bayes_pls_golite062009
rRNA methyltransferase activity	0.991198550579488	bayes_pls_golite062009
3'-5'-exoribonuclease activity	0.98640864840845	bayes_pls_golite062009
structure-specific DNA binding	0.707861773634749	bayes_pls_golite062009
	0.596347353533061	bayes_pls_golite062009
single-stranded DNA binding	0.567929700499153	bayes_pls_golite062009
transferase activity	0.269890329731988	bayes_pls_golite062009
catalytic activity	0.254696427664799	bayes_pls_golite062009
protein binding	0.0494791880947549	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [111-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVTPPNLLDT TFKKKNKLYL KCASTFPPLN QLPFMNASAE QHYKEGLSIA RDSSKGKSDD  60
   61 ALTNLVYIGK NQIITLSNQN IPNTARVTVD TERKEVVSPI DAYKGKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.39794
Match:	1k3rA_
Description:	Hypothetical protein MTH1 (MT0001), insert domain; Hypothetical protein MTH1 (MT0001), dimerisation domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: