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Protein Overview: RME1

General Information:
Name(s) found: RME1 / YGR044C [SGD]
Description(s) found:
Found 42 descriptions.
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  • Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 300 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    meiosis [TASLink to PubMed article]
    Molecular Function: specific transcriptional repressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPCYGQNSA IAKGSWNREV LQEVQPIYHW HDFGQNMKEY SASPLEGDSS LPSSLPSSTE  60
   61 DCLLLSLENT ITVIAGNQRQ AYDSTSSTEE GTAPQLRPDE IADSTHCITS LVDPEFRDLI 120
  121 NYGRQKGANP VFIESNTTEQ SHSQCILGYP QKSHVAQLYH DPKVLSTISE GQTKRGSYHC 180
  181 SHCSEKFATL VEFAAHLDEF NLERPCKCPI EQCPWKILGF QQATGLRRHC ASQHIGELDI 240
  241 EMEKSLNLKV EKYPGLNCPF PICQKTFRRK DAYKRHVAMV HNNADSRFNK RLKKILNNTK 300
  301

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YPT1 RME1 1 Unpublished Fields Lab Data
    View Screen ALG13 RME1 1 Hazbun TR, et al. (2003)
    View Screen PFK1 RME1 1 Unpublished Fields Lab Data
    View Screen ECM29 RME1 1 Unpublished Fields Lab Data
    View Screen ILM1 RME1 1 Lockshon D, et al. (2006)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RME1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..172] PSI-BLAST 15.69897 Transcription factor IIIA, TFIIIA
    2 View Details [173..251] PSI-BLAST 26.221849 Designed zinc finger protein
    3 View Details [252..300] PSI-BLAST 2.045757 Transcription factor sp1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle