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View Structure Prediction Details

Protein: RME1
Organism: Saccharomyces cerevisiae
Length: 300 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RME1.

Description E-value Query
Range
Subject
Range
gi|38382750, gi|... - gi|38382750|gb|AAH62309.1| Zinc finger protein 79 [Homo sapiens], gi|24307937|ref|NP_009066.1| zinc ...
gi|208968181 - gi|208968181|dbj|BAG73929.1| zinc finger protein 79 [synthetic construct]
0.0 [2..299] [195..485]
Z287_MOUSE, ZN28... - Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=1, (Q9EQB9) Zinc finger protein 287 (Zfp-2...
0.0 [2..296] [396..683]

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Predicted Domain #1
Region A:
Residues: [1-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPCYGQNSA IAKGSWNREV LQEVQPIYHW HDFGQNMKEY SASPLEGDSS LPSSLPSSTE  60
   61 DCLLLSLENT ITVIAGNQRQ AYDSTSSTEE GTAPQLRPDE IADSTHCITS LVDPEFRDLI 120
  121 NYGRQKGANP VFIESNTTEQ SHSQCILGYP QKSHVAQLYH DPKVLSTISE GQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1tf6A_
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [173-251]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKRGSYHCSH CSEKFATLVE FAAHLDEFNL ERPCKCPIEQ CPWKILGFQQ ATGLRRHCAS  60
   61 QHIGELDIEM EKSLNLKVE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.221849
Match: 1meyG_
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [252-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYPGLNCPFP ICQKTFRRKD AYKRHVAMVH NNADSRFNKR LKKILNNTK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.045757
Match: 1sp2__
Description: Transcription factor sp1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle