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Protein Overview: DOC1

General Information:
Name(s) found: DOC1 / YGL240W [SGD]
Description(s) found:
Found 13 descriptions.
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  • Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 283 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    cyclin catabolic process [TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    Molecular Function: enzyme regulator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQNKRRLYK RKKVLNKLTT EGGKNNTRFR SQIMDPIGIN KVLDHLAPSE LIKPVKSCHN  60
   61 KPSVLVLDDR IVDAATKDLY VNGFQEEIQY QNPTPENLQH MFHQGIEILD SARMINVTHL 120
  121 ALWKPSSFKL GNPVDFALDD NYDTFWQSDG GQPHQLDIMF SKRMDICVMA IFFSMIADES 180
  181 YAPSLVKVYA GHSPSDARFY KMLEVRNVNG WVALRFLDNR EDDQLLKCQF IRLLFPVNHE 240
  241 NGKDTHLRGI RLYVPSNEPH QDTHEWAQTL PETNNVFQDA ILR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..283] PSI-BLAST 1387.39794 APC10/DOC1 subunit of the anaphase-promoting complex


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle