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Protein Overview: PMR1

General Information:
Name(s) found: PMR1 / YGL167C [SGD]
Description(s) found:
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  • gi|971386|emb|CAA59762.1| calcium transporting ATPase 1 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||PWBYR1 Ca2+-transporting ATPase (EC 3.6.3.8) PMR1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6321271|ref|NP_011348.1| High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey [NCBI NR]
  • gi|172199|gb|AAA34884.1| PMR1 protein [NCBI NR]
  • gi|1322768|emb|CAA96880.1| PMR1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|114301|sp|P13586.1|ATC1_YEAST RecName: Full=Calcium-transporting ATPase 1; AltName: Full=Golgi Ca(2+)-ATPase; AltName: Full=Bypass SOD defects protein 1 [NCBI NR]
  • Calcium-transporting ATPase 1 OS=Saccharomyces cerevisiae GN=PMR1 PE=1 SV=1 [Swiss-Prot]
  • PMR1 Ca++-transporting P-type ATPase located in Golgi [mips]
  • High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease [SGD]
  • PMR1, Chr VII from 187620-190472, reverse complement [yeast_orfs2]
  • Chr VII from 187620-190472, reverse complement [yeastorf3.fasta]
  • Chr VII from 190472-187620, reverse complement [yeastorf5.fasta]
  • (P13586) Calcium-transporting ATPase 1 (EC 3.6.3.8) (Golgi Ca(2+)-ATPase) [4932.FASTACCERV.txt]
  • PMR1 SGDID:S0003135, Chr VII from 190472-187620, reverse complement, Verified ORF [yeastflysequest.fasta]
  • PMR1 SGDID:S0003135, Chr VII from 190474-187622, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • High affinity Ca2+/Mn2+ P-type ATPase, required for the transport of Ca2+ and Mn2+ into the Golgi; involved in Ca2+ dependent processes such as protein sorting, processing, and degradation [Saccharomyces cerevisiae]gi|1322768|emb|CAA96880.1| PMR1 [Saccha [nrdb_11152004_Chlamydomonas]
  • PMR1 SGDID:S000003135, Chr VII from 190474-187622, reverse complement, Verified ORF, "High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homo [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PMR1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PMR1 protein [nr-271106-contam.fasta]
  • High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; Pmr1p [Saccharomyc [nr-271106-contam.fasta]
  • Calcium-transporting ATPase 1 (Golgi Ca(2+)-ATPase) [nr-271106-contam.fasta]
  • calcium transporting ATPase 1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PMR1 SGDID:S000003135, Chr VII from 190474-187622, reverse complement, Verified ORF, "High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Calcium-transporting ATPase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PMR1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PMR1 SGDID:S000003135, Chr VII from 190468-187616, Genome Release 64-1-1, reverse complement, Verified ORF, "High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease" [yeast-030211-contam.fasta]
  • PMR1 SGDID:S000003135, Chr VII from 190468-187616, Genome Release 64-2-1, reverse complement, Verified ORF, "High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen appears to be required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease" [20141208_orf_trans.fasta]
  • YGL167C SGDID:S000003135, Chr VII from 190468-187616, Genome Release 64-1-1, reverse complement, Verified ORF, "High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 950 amino acids

    Gene Ontology:
    Cellular Component: Golgi membrane [IDALink to PubMed article]
    Biological Process: manganese ion transport [IDALink to PubMed article]
    secretory pathway [IMPLink to PubMed article]
    calcium ion transport [IDALink to PubMed article][IMPLink to PubMed article]
    protein amino acid glycosylation [IMPLink to PubMed article]
    Molecular Function: manganese-transporting ATPase activity [IDALink to PubMed article]
    calcium ion binding [IDALink to PubMed article]
    calcium-transporting ATPase activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDNPFNASL LDEDSNRERE ILDATAEALS KPSPSLEYCT LSVDEALEKL DTDKNGGLRS  60
   61 SNEANNRRSL YGPNEITVED DESLFKKFLS NFIEDRMILL LIGSAVVSLF MGNIDDAVSI 120
  121 TLAIFIVVTV GFVQEYRSEK SLEALNKLVP AECHLMRCGQ ESHVLASTLV PGDLVHFRIG 180
  181 DRIPADIRII EAIDLSIDES NLTGENEPVH KTSQTIEKSS FNDQPNSIVP ISERSCIAYM 240
  241 GTLVKEGHGK GIVVGTGTNT SFGAVFEMMN NIEKPKTPLQ LTMDKLGKDL SLVSFIVIGM 300
  301 ICLVGIIQGR SWLEMFQISV SLAVAAIPEG LPIIVTVTLA LGVLRMAKRK AIVRRLPSVE 360
  361 TLGSVNVICS DKTGTLTSNH MTVSKLWCLD SMSNKLNVLS LDKNKKTKNS NGNLKNYLTE 420
  421 DVRETLTIGN LCNNASFSQE HAIFLGNPTD VALLEQLANF EMPDIRNTVQ KVQELPFNSK 480
  481 RKLMATKILN PVDNKCTVYV KGAFERILEY STSYLKSKGK KTEKLTEAQK ATINECANSM 540
  541 ASEGLRVFGF AKLTLSDSST PLTEDLIKDL TFTGLIGMND PPRPNVKFAI EQLLQGGVHI 600
  601 IMITGDSENT AVNIAKQIGI PVIDPKLSVL SGDKLDEMSD DQLANVIDHV NIFARATPEH 660
  661 KLNIVRALRK RGDVVAMTGD GVNDAPALKL SDIGVSMGRI GTDVAKEASD MVLTDDDFST 720
  721 ILTAIEEGKG IFNNIQNFLT FQLSTSVAAL SLVALSTAFK LPNPLNAMQI LWINILMDGP 780
  781 PAQSLGVEPV DHEVMKKPPR KRTDKILTHD VMKRLLTTAA CIIVGTVYIF VKEMAEDGKV 840
  841 TARDTTMTFT CFVFFDMFNA LACRHNTKSI FEIGFFTNKM FNYAVGLSLL GQMCAIYIPF 900
  901 FQSIFKTEKL GISDILLLLL ISSSVFIVDE LRKLWTRKKN EEDSTYFSNV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AAC3 ATG32 HXT7 PET9 PMR1
    View Details Gavin AC, et al. (2006) PMR1 RVB2 SEC53
    View Details Qiu et al. (2008) CAX4 CCC2 NEO1 PHO84 PMR1 ZRT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PMR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78]
    [151..273]    		 PSI-BLAST 2130.0 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    2 View Details [79..140]
    [274..338]
    [731..950]    		 PSI-BLAST 2130.0 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    3 View Details [141..150]
    [339..378]
    [582..730]    		 PSI-BLAST 2130.0 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    4 View Details [379..581] PSI-BLAST 2130.0 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle