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Protein Overview: YFL054C

General Information:
Name(s) found: YFL054C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 646 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISSLink to PubMed article]
    Biological Process: water transport [ISSLink to PubMed article]
    Molecular Function: glycerol transmembrane transporter activity [ISSLink to PubMed article]
    water channel activity [ISSLink to PubMed article]
    transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYESGRSSS SSESTRPPTL KEEPNGKIAW EESVKKSREN NENDSTLLRR KLGETRKAIE  60
   61 TGGSSRNKLS ALTPLKKVVD ERKDSVQPQV PSMGFTYSLP NLKTLNSFSD AEQARIMQDY 120
  121 LSRGVNQGNS NNYVDPLYRQ LNPTMGSSRN RPVWSLNQPL PHVLDRGLAA KMIQKNMDAR 180
  181 SRASSRRGST DISRGGSTTS VKDWKRLLRG AAPGKKLGDI EAQTQRDNTV GADVKPTKLE 240
  241 PENPQKPSNT HIENVSRKKK RTSHNVNFSL GDESYASSIA DAESRKLKNM QTLDGSTPVY 300
  301 TKLPEELIEE ENKSTSALDG NEIGASEDED ADIMTFPNFW AKIRYHMREP FAEFLGTLVL 360
  361 VIFGVGGNLQ ATVTKGSGGS YESLSFAWGF GCMLGVYVAG GISGGHINPA VTISMAIFRK 420
  421 FPWKKVPVYI VAQIIGAYFG GAMAYGYFWS SITEFEGGPH IRTTATGACL FTDPKSYVTW 480
  481 RNAFFDEFIG ASILVGCLMA LLDDSNAPPG NGMTALIIGF LVAAIGMALG YQTSFTINPA 540
  541 RDLGPRIFAS MIGYGPHAFH LTHWWWTWGA WGGPIAGGIA GALIYDIFIF TGCESPVNYP 600
  601 DNGYIENRVG KLLHAEFHQN DGTVSDESGV NSNSNTGSKK SVPTSS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ELM1 GIS4 MRP8 YEL043W YFL054C
    View Details Qiu et al. (2008) AQY1 YFL054C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] MSA 2.004996 View MSA. No confident structure predictions are available.
    2 View Details [237..326] deduced N/A No confident structure predictions are available.
    3 View Details [327..460] PSI-BLAST 496.70927 Glycerol uptake facilitator protein GlpF
    4 View Details [461..646] PSI-BLAST 496.70927 Glycerol uptake facilitator protein GlpF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • water transmembrane transporter activity
    		•  10.0147296433934 bayes_pls_golite062009
  • water channel activity
    		•  9.90182460707078 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  6.84984722645819 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  6.65010837320829 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  6.65010837320829 bayes_pls_golite062009
  • transporter activity
    		•  5.23077472964938 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.0695479460357 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  5.06520190871345 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.06054430984045 bayes_pls_golite062009
  • channel activity
    		•  5.06054430984045 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  4.83314424546299 bayes_pls_golite062009
  • glycerol channel activity
    		•  4.20153412116491 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.82456291801633 bayes_pls_golite062009
  • pyrimidine transmembrane transporter activity
    		•  2.16047489562591 bayes_pls_golite062009
  • purine transmembrane transporter activity
    		•  1.87440278697248 bayes_pls_golite062009
  • nucleobase transmembrane transporter activity
    		•  1.87440278697248 bayes_pls_golite062009
  • binding
    		•  0.629257163572322 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.516648340085278 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.315342449421593 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.141210715822635 bayes_pls_golite062009
  • urea channel activity
    		•  0.104970224967194 bayes_pls_golite062009
  • urea transmembrane transporter activity
    		•  0.104970224967194 bayes_pls_golite062009
  • amide transmembrane transporter activity
    		•  0.104970224967194 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0368961725897963 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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