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View Structure Prediction Details

Protein: YFL054C
Organism: Saccharomyces cerevisiae
Length: 646 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFL054C.

Description E-value Query
Range		 Subject
Range
gi|151944919 - gi|151944919|gb|EDN63174.1| conserved protein [Saccharomyces cerevisiae YJM789]
YFL054C - Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the prese...
YFF4_YEAST - Uncharacterized membrane protein YFL054C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
 0.0 [1..646] [1..646]
SPAC977.17 - MIP water channel
YI7H_SCHPO - Uncharacterized membrane protein C977.17 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=S...
 0.0 [97..615] [61..578]
PIP12_MAIZE - Aquaporin PIP1-2 OS=Zea mays GN=PIP1-2 PE=1 SV=1
 1.0E-96 [305..591] [1..282]
gi|2373401 - gi|2373401|dbj|BAA22097.1| transmembrane protein [Arabidopsis thaliana]
 6.0E-96 [305..591] [1..280]
gi|3551131 - gi|3551131|dbj|BAA32777.1| plasma membrane aquaporin (PAQ1) [Raphanus sativus]
 7.0E-96 [305..591] [1..279]
gi|6692753 - gi|6692753|dbj|BAA23746.2| HvPIP1;5 [Hordeum vulgare subsp. vulgare]
 8.0E-96 [305..591] [1..282]
gi|125540600 - gi|125540600|gb|EAY86995.1| hypothetical protein OsI_08388 [Oryza sativa Indica Group]
PIP11_ORYSA - Aquaporin PIP1.1 (Plasma membrane intrinsic protein 1a) (PIP1a) (OsPIP1.1) (Water channel protein RW...
PIP11_ORYSJ - Aquaporin PIP1-1 OS=Oryza sativa subsp. japonica GN=PIP1-1 PE=2 SV=1
 9.0E-96 [305..591] [1..282]
gi|2199574|gb|AA... - aquaporin [Brassica rapa]
gi|2199574 - gi|2199574|gb|AAB61378.1| aquaporin [Brassica rapa]
 1.0E-95 [305..591] [1..279]

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Predicted Domain #1
Region A:
Residues: [1-236] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYESGRSSS SSESTRPPTL KEEPNGKIAW EESVKKSREN NENDSTLLRR KLGETRKAIE  60
   61 TGGSSRNKLS ALTPLKKVVD ERKDSVQPQV PSMGFTYSLP NLKTLNSFSD AEQARIMQDY 120
  121 LSRGVNQGNS NNYVDPLYRQ LNPTMGSSRN RPVWSLNQPL PHVLDRGLAA KMIQKNMDAR 180
  181 SRASSRRGST DISRGGSTTS VKDWKRLLRG AAPGKKLGDI EAQTQRDNTV GADVKP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [237-326] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKLEPENPQK PSNTHIENVS RKKKRTSHNV NFSLGDESYA SSIADAESRK LKNMQTLDGS  60
   61 TPVYTKLPEE LIEEENKSTS ALDGNEIGAS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [327-460] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDEDADIMTF PNFWAKIRYH MREPFAEFLG TLVLVIFGVG GNLQATVTKG SGGSYESLSF  60
   61 AWGFGCMLGV YVAGGISGGH INPAVTISMA IFRKFPWKKV PVYIVAQIIG AYFGGAMAYG 120
  121 YFWSSITEFE GGPH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 496.70927
Match: 1fx8A_
Description: Glycerol uptake facilitator protein GlpF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
water transmembrane transporter activity 10.0147296433934 bayes_pls_golite062009
water channel activity 9.90182460707078 bayes_pls_golite062009
glycerol transmembrane transporter activity 6.84984722645819 bayes_pls_golite062009
polyol transmembrane transporter activity 6.65010837320829 bayes_pls_golite062009
alcohol transmembrane transporter activity 6.65010837320829 bayes_pls_golite062009
transporter activity 5.23077472964938 bayes_pls_golite062009
substrate-specific channel activity 5.0695479460357 bayes_pls_golite062009
substrate-specific transporter activity 5.06520190871345 bayes_pls_golite062009
passive transmembrane transporter activity 5.06054430984045 bayes_pls_golite062009
channel activity 5.06054430984045 bayes_pls_golite062009
transmembrane transporter activity 4.83314424546299 bayes_pls_golite062009
glycerol channel activity 4.20153412116491 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.82456291801633 bayes_pls_golite062009
pyrimidine transmembrane transporter activity 2.16047489562591 bayes_pls_golite062009
purine transmembrane transporter activity 1.87440278697248 bayes_pls_golite062009
nucleobase transmembrane transporter activity 1.87440278697248 bayes_pls_golite062009
binding 0.629257163572322 bayes_pls_golite062009
ion transmembrane transporter activity 0.516648340085278 bayes_pls_golite062009
active transmembrane transporter activity 0.315342449421593 bayes_pls_golite062009
cation transmembrane transporter activity 0.141210715822635 bayes_pls_golite062009
urea channel activity 0.104970224967194 bayes_pls_golite062009
urea transmembrane transporter activity 0.104970224967194 bayes_pls_golite062009
amide transmembrane transporter activity 0.104970224967194 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0368961725897963 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [461-646] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRTTATGACL FTDPKSYVTW RNAFFDEFIG ASILVGCLMA LLDDSNAPPG NGMTALIIGF  60
   61 LVAAIGMALG YQTSFTINPA RDLGPRIFAS MIGYGPHAFH LTHWWWTWGA WGGPIAGGIA 120
  121 GALIYDIFIF TGCESPVNYP DNGYIENRVG KLLHAEFHQN DGTVSDESGV NSNSNTGSKK 180
  181 SVPTSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 496.70927
Match: 1fx8A_
Description: Glycerol uptake facilitator protein GlpF
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle