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View Structure Prediction Details

Protein: YFL054C
Organism: Saccharomyces cerevisiae
Length: 646 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFL054C.

Description E-value Query
Range
Subject
Range
gi|151944919 - gi|151944919|gb|EDN63174.1| conserved protein [Saccharomyces cerevisiae YJM789]
YFL054C - Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the prese...
YFF4_YEAST - Uncharacterized membrane protein YFL054C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
0.0 [1..646] [1..646]
SPAC977.17 - MIP water channel
YI7H_SCHPO - Uncharacterized membrane protein C977.17 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=S...
0.0 [97..615] [61..578]
PIP12_MAIZE - Aquaporin PIP1-2 OS=Zea mays GN=PIP1-2 PE=1 SV=1
1.0E-96 [305..591] [1..282]
gi|2373401 - gi|2373401|dbj|BAA22097.1| transmembrane protein [Arabidopsis thaliana]
6.0E-96 [305..591] [1..280]
gi|3551131 - gi|3551131|dbj|BAA32777.1| plasma membrane aquaporin (PAQ1) [Raphanus sativus]
7.0E-96 [305..591] [1..279]
gi|6692753 - gi|6692753|dbj|BAA23746.2| HvPIP1;5 [Hordeum vulgare subsp. vulgare]
8.0E-96 [305..591] [1..282]
gi|125540600 - gi|125540600|gb|EAY86995.1| hypothetical protein OsI_08388 [Oryza sativa Indica Group]
PIP11_ORYSA - Aquaporin PIP1.1 (Plasma membrane intrinsic protein 1a) (PIP1a) (OsPIP1.1) (Water channel protein RW...
PIP11_ORYSJ - Aquaporin PIP1-1 OS=Oryza sativa subsp. japonica GN=PIP1-1 PE=2 SV=1
9.0E-96 [305..591] [1..282]
gi|2199574|gb|AA... - aquaporin [Brassica rapa]
gi|2199574 - gi|2199574|gb|AAB61378.1| aquaporin [Brassica rapa]
1.0E-95 [305..591] [1..279]

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Predicted Domain #1
Region A:
Residues: [1-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYESGRSSS SSESTRPPTL KEEPNGKIAW EESVKKSREN NENDSTLLRR KLGETRKAIE  60
   61 TGGSSRNKLS ALTPLKKVVD ERKDSVQPQV PSMGFTYSLP NLKTLNSFSD AEQARIMQDY 120
  121 LSRGVNQGNS NNYVDPLYRQ LNPTMGSSRN RPVWSLNQPL PHVLDRGLAA KMIQKNMDAR 180
  181 SRASSRRGST DISRGGSTTS VKDWKRLLRG AAPGKKLGDI EAQTQRDNTV GADVKP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [237-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKLEPENPQK PSNTHIENVS RKKKRTSHNV NFSLGDESYA SSIADAESRK LKNMQTLDGS  60
   61 TPVYTKLPEE LIEEENKSTS ALDGNEIGAS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.560 a.77.1 DEATH domain
View Download 0.384 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.557 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.498 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.384 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.383 a.77.1 DEATH domain
View Download 0.381 c.9.1 Barstar (barnase inhibitor)
View Download 0.369 a.134.1 Fungal elicitin
View Download 0.361 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.351 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.320 a.47.2 t-snare proteins
View Download 0.312 a.77.1 DEATH domain
View Download 0.311 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.287 a.4.1 Homeodomain-like
View Download 0.251 a.28.1 ACP-like
View Download 0.237 a.158.1 F-box domain
View Download 0.234 a.64.1 Saposin
View Download 0.204 a.141.1 Frizzled cystein-rich domain

Predicted Domain #3
Region A:
Residues: [327-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDEDADIMTF PNFWAKIRYH MREPFAEFLG TLVLVIFGVG GNLQATVTKG SGGSYESLSF  60
   61 AWGFGCMLGV YVAGGISGGH INPAVTISMA IFRKFPWKKV PVYIVAQIIG AYFGGAMAYG 120
  121 YFWSSITEFE GGPH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 496.70927
Match: 1fx8A_
Description: Glycerol uptake facilitator protein GlpF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
water transmembrane transporter activity 10.0147296433934 bayes_pls_golite062009
water channel activity 9.90182460707078 bayes_pls_golite062009
glycerol transmembrane transporter activity 6.84984722645819 bayes_pls_golite062009
polyol transmembrane transporter activity 6.65010837320829 bayes_pls_golite062009
alcohol transmembrane transporter activity 6.65010837320829 bayes_pls_golite062009
transporter activity 5.23077472964938 bayes_pls_golite062009
substrate-specific channel activity 5.0695479460357 bayes_pls_golite062009
substrate-specific transporter activity 5.06520190871345 bayes_pls_golite062009
passive transmembrane transporter activity 5.06054430984045 bayes_pls_golite062009
channel activity 5.06054430984045 bayes_pls_golite062009
transmembrane transporter activity 4.83314424546299 bayes_pls_golite062009
glycerol channel activity 4.20153412116491 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.82456291801633 bayes_pls_golite062009
pyrimidine transmembrane transporter activity 2.16047489562591 bayes_pls_golite062009
purine transmembrane transporter activity 1.87440278697248 bayes_pls_golite062009
nucleobase transmembrane transporter activity 1.87440278697248 bayes_pls_golite062009
binding 0.629257163572322 bayes_pls_golite062009
ion transmembrane transporter activity 0.516648340085278 bayes_pls_golite062009
active transmembrane transporter activity 0.315342449421593 bayes_pls_golite062009
cation transmembrane transporter activity 0.141210715822635 bayes_pls_golite062009
urea channel activity 0.104970224967194 bayes_pls_golite062009
urea transmembrane transporter activity 0.104970224967194 bayes_pls_golite062009
amide transmembrane transporter activity 0.104970224967194 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0368961725897963 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [461-646]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRTTATGACL FTDPKSYVTW RNAFFDEFIG ASILVGCLMA LLDDSNAPPG NGMTALIIGF  60
   61 LVAAIGMALG YQTSFTINPA RDLGPRIFAS MIGYGPHAFH LTHWWWTWGA WGGPIAGGIA 120
  121 GALIYDIFIF TGCESPVNYP DNGYIENRVG KLLHAEFHQN DGTVSDESGV NSNSNTGSKK 180
  181 SVPTSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 496.70927
Match: 1fx8A_
Description: Glycerol uptake facilitator protein GlpF
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle