Protein Overview: AVT6

General Information:
Name(s) found:	AVT6 / YER119C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731507\|sp\|P40074.1\|AVT6_YEAST RecName: Full=Vacuolar amino acid transporter 6 [NCBI NR] gi\|6320965\|ref\|NP_011044.1\| Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt6p [Saccharomyces cerevisiae] [NCBI NR] gi\|603358\|gb\|AAC03217.1\| Yer119cp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50622 hypothetical protein YER119c - yeast (Saccharomyces cerevisiae) [NCBI NR] (P40074) Hypothetical 48.8 kDa protein in SSU81-SCS2 intergenic region [Swiss-Prot] Vacuolar amino acid transporter 6 OS=Saccharomyces cerevisiae GN=AVT6 PE=1 SV=1 [Swiss-Prot] AVT6 Protein involved in amino acid efflux from the vacuole [mips] Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation [SGD] YER119C, Chr V from 399492-400838, reverse complement [yeast_orfs2] Chr V from 399492-400838, reverse complement [yeastorf3.fasta] Chr V from 400838-399492, reverse complement [yeastorf5.fasta] AVT6 SGDID:S0000921, Chr V from 400838-399492, reverse complement, Verified ORF [yeastflysequest.fasta] Avt6p [Saccharomyces cerevisiae]gi\|603358\|gb\|AAC03217.1\| Yer119cp [Saccharomyces cerevisiae]gi\|731507\|sp\|P40074\|YEU9_YEAST Hypothetical 48.8 kDa protein in SSU81-SCS2 intergenic regiongi\|1077700\|pir\|\|S50622 hypothetical protein YER119c - yeast (Sacchar [nrdb_11152004_Chlamydomonas] AVT6 SGDID:S000000921, Chr V from 400838-399492, reverse complement, Verified ORF, "Vacuolar transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transpor [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] AVT6 SGDID:S000000921, Chr V from 400838-399492, reverse complement, Verified ORF, "Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glyci [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Vacuolar transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Yer119cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Vacuolar amino acid transporter 6 [nr-271106-contam.fasta] AVT6 SGDID:S000000921, Chr V from 400838-399492, reverse complement, Verified ORF, "Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" [yeast-bovrabprots.fasta] AVT6 SGDID:S000000921, Chr V from 400838-399492, reverse complement, Verified ORF, "Vacuolar transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" [yeast-contam_custom.fasta] [chemostatdb.fasta] Vacuolar amino acid transporter 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AVT6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] AVT6 SGDID:S000000921, Chr V from 400842-399496, Genome Release 64-1-1, reverse complement, Verified ORF, "Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation" [yeast-030211-contam.fasta] AVT6 SGDID:S000000921, Chr V from 400842-399496, Genome Release 64-2-1, reverse complement, Verified ORF, "Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YER119C SGDID:S000000921, Chr V from 400842-399496, Genome Release 64-1-1, reverse complement, Verified ORF, "Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	448 amino acids
Gene Ontology:
Cellular Component:	fungal-type vacuole membrane [IMP] vacuole [IDA]
Biological Process:	vacuolar transport [IMP] amino acid transport [IMP]
Molecular Function:	L-aspartate transmembrane transporter activity [IMP] transporter activity [ISS] L-glutamate transmembrane transporter activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVASIRSGVL TLLHTACGAG ILAMPYAFKP FGLIPGVIMI VLCGACAMQS LFIQARVAKY  60
   61 VPQGRASFSA LTRLINPNLG IVFDLAIAIK CFGVGVSYMI VVGDLMPQIM SVWTRNAWLL 120
  121 NRNVQISLIM LFFVAPLSFL KKLNSLRYAS MVAISSVAYL CVLVLLHYVA PSDEILRLKG 180
  181 RISYLLPPQS HDLNVLNTLP IFVFAYTCHH NMFSIINEQR SSRFEHVMKI PLIAISLALI 240
  241 LYIAIGCAGY LTFGDNIIGN IIMLYPQAVS STIGRIAIVL LVMLAFPLQC HPARASIHQI 300
  301 LQHFAEENVS ISATSADEPT VATESSPLIR DSSLDLNEVI EEESIYQPKE TPLRGKSFIV 360
  361 ITCSILVASY LVAISVSSLA RVLAIVGATG STSISFILPG LFGYKLIGTE HKTAVPLTTK 420
  421 IFKYTGLLLF IWGLIIMITC LTAALKLN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		AGP2 AVT1 AVT4 AVT6 GAP1 TPO4 VBA1 VMA9

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#13 Mitotic Prep2-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD1	AVT6	2	Unpublished Fields Lab Data
View Screen	RAD51	AVT6	1	Unpublished Fields Lab Data
View Screen	GLC7	AVT6	1	Unpublished Fields Lab Data
View Screen	RED1	AVT6	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..448]	Pfam	138.60206	Transmembrane amino acid transporter protein No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2