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Protein Overview: SIT1

General Information:
Name(s) found: SIT1 / YEL065W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 628 amino acids

    Gene Ontology:
    Cellular Component: endosome [TASLink to PubMed article]
    cytoplasmic membrane-bounded vesicle [IDALink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IDALink to PubMed article][IMPLink to PubMed article]
    siderophore-iron transport [IMPLink to PubMed article]
    Molecular Function: siderophore-iron (ferrioxamine) uptake transmembrane transporter activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPGIANHTL PEEFEEVVVP EMLEKEVGAK VDVKPTLTTS SPAPSYIELI DPGVHNIEIY  60
   61 AEMYNRPIYR VALFFSLFLI AYAYGLDGNI RYTFQAYATS SYSQHSLLST VNCIKTVIAA 120
  121 VGQIFFARLS DIFGRFSIMI VSIIFYSMGT IIESQAVNIT RFAVGGCFYQ LGLTGIILIL 180
  181 EVIASDFSNL NWRLLALFIP ALPFIINTWI SGNVTSAIDA NWKWGIGMWA FILPLACIPL 240
  241 GICMLHMRYL ARKHAKDRLK PEFEALNKLK WKSFCIDIAF WKLDIIGMLL ITVFFGCVLV 300
  301 PFTLAGGLKE EWKTAHIIVP EVIGWVVVLP LYMLWEIKYS RHPLTPWDLI QDRGIFFALL 360
  361 IAFFINFNWY MQGDYMYTVL VVAVHESIKS ATRITSLYSF VSVIVGTILG FILIKVRRTK 420
  421 PFIIFGISCW IVSFGLLVHY RGDSGAHSGI IGSLCLLGFG AGSFTYVTQA SIQASAKTHA 480
  481 RMAVVTSLYL ATYNIGSAFG SSVSGAVWTN ILPKEISKRI SDPTLAAQAY GSPFTFITTY 540
  541 TWGTPERIAL VMSYRYVQKI LCIIGLVFCF PLLGCAFMLR NHKLTDSIAL EGNDHLESKN 600
  601 TFEIEEKEES FLKNKFFTHF TSSKDRKD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ARN1 ARN2 ENB1 SIT1 SMF2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..268] PSI-BLAST 5.39794 No description for 1ja5A_ was found.
    2 View Details [269..343] deduced N/A No confident structure predictions are available.
    3 View Details [344..628] MSA 17.659996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  5.46247398538901 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.58978526526921 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.31967711223954 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • binding
    		•  1.26757615356623 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  1.24023641504332 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle