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Protein Overview: SMF2

General Information:
Name(s) found: SMF2 / YHR050W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 549 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cytoplasmic membrane-bounded vesicle [IDALink to PubMed article]
    Biological Process: manganese ion transport [IGILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: manganese ion transmembrane transporter activity [IGILink to PubMed article][ISSLink to PubMed article]
    di-, tri-valent inorganic cation transmembrane transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSQEYEPIQ WSDESQTNND SVNDAYADVN TTHESRRRTT LQPNSTSQSM IGTLRKYARF  60
   61 IGPGLMVSVS YMDPGNYSTA VAAGSAHRYK LLFSVLVSNF MAAFWQYLCA RLGAVTGLDL 120
  121 AQNCKKHLPF GLNITLYILA EMAIIATDLA EVVGTAISLN ILFHIPLALG VILTVVDVLI 180
  181 VLLAYKPNGS MKGIRIFEAF VSLLVVLTVV CFTVELFYAK LGPAKEIFSG FLPSKAVFEG 240
  241 DGLYLSLAIL GATVMPHSLY LGSGVVQPRL REYDIKNGHY LPDANDMDNN HDNYRPSYEA 300
  301 ISETLHFTIT ELLISLFTVA LFVNCAILIV SGATLYGSTQ NAEEADLFSI YNLLCSTLSK 360
  361 GAGTVFVLAL LFSGQSAGIV CTLSGQMVSE GFLNWTVSPA LRRSATRAVA ITPCLILVLV 420
  421 AGRSGLSGAL NASQVVLSLL LPFVSAPLLY FTSSKKIMRV QLNRTKELSR TTDKKPVADR 480
  481 TEDDETIELE EMGIGSSSQE RSLVSPAPEY KDMSNGMIVT VLAIIVWLII SGLNFYMLLG 540
  541 FTTGKEVHL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ARN1 SIT1 SMF2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] deduced N/A No confident structure predictions are available.
    2 View Details [76..495] Pfam 242.886057 Natural resistance-associated macrophage protein No confident structure predictions are available.
    3 View Details [496..549] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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