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Protein Overview: SLF1

General Information:
Name(s) found: SLF1 / YDR515W [SGD]
Description(s) found:
Found 33 descriptions.
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  • RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 447 amino acids

    Gene Ontology:
    Cellular Component: polysome [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: regulation of translation [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    cellular copper ion homeostasis [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQNLNDNP KNTSSAAEDK KKQTSSLKLA PIPTTSPWKS SSPDSNTVIP VEELRDISKT  60
   61 AKPSKNGSGS IKLTSNTKWT PITPSVIISG SKDTNSKSGK NSKNSKTNKK MKKRGKYNND 120
  121 INKKDFNGQT NSTSEISNVS NLESKPLDAN AKVNIHSSSG ATANGNIKRI TNNNNSTNGR 180
  181 QSRNYQNRNG KTRYNNNSRH SQAANNAISF PNNYQARPEY IPNASHWLNN NSRNSYKQLS 240
  241 YFRQQQYYNN INYQQQLQTP YYYSMEPIFK SIESIKNQIE FYFSEENLKT DEFLRSKFKK 300
  301 ANDGFIPMSL IGKFYRMVNL SLGGDPNLIL ASMREVLQHK ETNHLEIALG SIEGAQKNMA 360
  361 DDFNPLENYF IRRENWAEYA MESNFDENDD ETEKYNIEKL LGPNDLDNYS YMGYPNFFPS 420
  421 NENGKKSQSY DQGEISRQFE QNLQIND

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAF20 CDC33 EAP1 PSP2 SLF1 TIF1, TIF2 TIF4631 TIF4632 YOR287C
    View Details Qiu et al. (2008) PBP1 SLF1 SSB1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SNF4 SLF1 1 Unpublished Fields Lab Data
    View Screen UBC7 SLF1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SLF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..257] ORFEUS 14.16 RBP1
    2 View Details [258..363] MSA 6.075982 View MSA. No confident structure predictions are available.
    3 View Details [364..447] MSA 2.037994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mRNA binding
    		•  4.52007814408702 bayes_pls_golite062009
  • RNA binding
    		•  4.50438526063124 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.64594243387558 bayes_pls_golite062009
  • binding
    		•  3.00411894202318 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.95301685898669 bayes_pls_golite062009
  • structural molecule activity
    		•  2.78501986457503 bayes_pls_golite062009
    		• 1.49431666307335 bayes_pls_golite062009
  • poly(U) RNA binding
    		•  1.35467931535417 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.90573796517364 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.737458867828906 bayes_pls_golite062009
  • DNA binding
    		•  0.691258294213766 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.599389001184667 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.32812362201346 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle