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Protein Overview: CAF20

General Information:
Name(s) found: CAF20 / YOR276W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 161 amino acids

    Gene Ontology:
    Cellular Component: mRNA cap binding complex [IPILink to PubMed article]
    Biological Process: negative regulation of translation [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: translation regulator activity [IGILink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKYTIDELF QLKPSLTLEV NFDAVEFRAI IEKVKQLQHL KEEEFNSHHV GHFGRRRSSH  60
   61 HHGRPKIKHN KPKVTTDSDG WCTFEAKKKG SGEDDEEETE TTPTSTVPVA TIAQETLKVK 120
  121 PNNKNISSNR PADTRDIVAD KPILGFNAFA ALESEDEDDE A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAF20 CDC33
    View Details (MIPS) Mewes HW, et al. (2004) CAF20 TIF4631 TIF4632
    View Details Krogan NJ, et al. (2006) CAF20 CDC33 EAP1 PSP2 SLF1 TIF1, TIF2 TIF4631 TIF4632 YOR287C
    View Details Ho Y, et al. (2002) CAF20 CDC33 GAL83 NAP1
    View Details Qiu et al. (2008) CAF20 EAP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CAF20 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle