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Protein Overview: PEP7

General Information:
Name(s) found: PEP7 / YDR323C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 515 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    external side of endosome membrane [IDALink to PubMed article]
    Biological Process: vesicle fusion [IMPLink to PubMed article]
    vesicle docking during exocytosis [IMPLink to PubMed article]
    Golgi to vacuole transport [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: phosphatidylinositol-3-phosphate binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLENVSCPI CLRKFDNLQA LNAHLDVEHG FNDNEDSLGS NDSRLVNGKQ KKARSVDSSA  60
   61 QKLKRSHWEK FKKGKSCCHT CGRTLNNNIG AINCRKCGKL YCRRHLPNMI KLNLSAQYDP 120
  121 RNGKWYNCCH DCFVTKPGYN DYGEVIDLTP EFFKVRNIKR EDKNLRLLQL ENRFVRLVDG 180
  181 LITLYNTYSR SIIHNLKMNS EMSKLERTVT PWRDDRSVLF CNICSEPFGL LLRKHHCRLC 240
  241 GMVVCDDANR NCSNEISIGY LMSAASDLPF EYNIQKDDLL HIPISIRLCS HCIDMLFIGR 300
  301 KFNKDVRMPL SGIFAKYDSM QNISKVIDSL LPIFEDSLNS LKVETAKDSE NTLDPKNLND 360
  361 LARLRHKLLN SFNLYNTLTR QLLSVEPQSH LERQLQNSIK IASAAYINEK ILPLKSLPAI 420
  421 LNPEGHKTNE DGQKAEPEVK KLSQLMIENL TIKEVKELRE ELMVLKEQSY LIESTIQDYK 480
  481 KQRRLEEIVT LNKNLEELHS RIHTVQSKLG DHGFN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) PEP3 PEP7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ARG1 PEP7 1 Unpublished Fields Lab Data
    View Screen HMT1 PEP7 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PEP7 and SNF7 Huh WK, et al. (2003)
    View Data PEP7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] ORFEUS 10.91 Hrs
    2 View Details [159..307] PSI-BLAST 53.69897 vps27p protein
    3 View Details [308..515] MSA 12.085997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • clathrin binding
    		•  4.23430630035276 bayes_pls_golite062009
  • binding
    		•  2.35694469334775 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.5307798253901 bayes_pls_golite062009
  • protein binding
    		•  1.44642175542767 bayes_pls_golite062009
  • phospholipid binding
    		•  1.34712325037196 bayes_pls_golite062009
  • transporter activity
    		•  1.32696426532114 bayes_pls_golite062009
  • ADP-ribosylation factor binding
    		•  1.08699679453397 bayes_pls_golite062009
  • protein transporter activity
    		•  1.00558105390757 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.934511830388366 bayes_pls_golite062009
  • histone binding
    		•  0.75399983087006 bayes_pls_golite062009
  • phosphatidylinositol binding
    		•  0.67214549237381 bayes_pls_golite062009
  • lipid binding
    		•  0.131242568396849 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0347989334053008 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle