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View Structure Prediction Details

Protein: PEP7
Organism: Saccharomyces cerevisiae
Length: 515 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEP7.

Description E-value Query
Range
Subject
Range
PEP7_YEAST - Vacuolar segregation protein PEP7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEP7 P...
PEP7 - Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring h...
gi|151942300 - gi|151942300|gb|EDN60656.1| carboxypeptidase Y-deficient [Saccharomyces cerevisiae YJM789]
0.0 [1..515] [1..515]
PEP7_SCHPO - Vacuolar segregation protein pep7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pep7 PE=...
pep7 - prevacuole /endosomal FYVE tethering component Pep7
2.0E-69 [8..511] [41..530]
gi|13874596 - gi|13874596|dbj|BAB46907.1| hypothetical protein [Macaca fascicularis]
6.0E-52 [4..508] [12..502]
gi|15222423, gi|... - pir||A96719 hypothetical protein T6C23.9 [imported] - Arabidopsis thaliana, gi|15222423|ref|NP_1771...
3.0E-47 [176..507] [594..917]
gi|12860304 - gi|12860304|dbj|BAB31910.1| unnamed protein product [Mus musculus]
5.0E-46 [4..424] [12..382]
rabs-5 - status:Partially_confirmed UniProt:Q9N3Y4 protein_id:AAF60562.3
4.0E-43 [4..452] [19..471]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLENVSCPI CLRKFDNLQA LNAHLDVEHG FNDNEDSLGS NDSRLVNGKQ KKARSVDSSA  60
   61 QKLKRSHWEK FKKGKSCCHT CGRTLNNNIG AINCRKCGKL YCRRHLPNMI KLNLSAQYDP 120
  121 RNGKWYNCCH DCFVTKPGYN DYGEVIDLTP EFFKVRNI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.91
Match: 1dvpA
Description: Hrs
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [159-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KREDKNLRLL QLENRFVRLV DGLITLYNTY SRSIIHNLKM NSEMSKLERT VTPWRDDRSV  60
   61 LFCNICSEPF GLLLRKHHCR LCGMVVCDDA NRNCSNEISI GYLMSAASDL PFEYNIQKDD 120
  121 LLHIPISIRL CSHCIDMLFI GRKFNKDVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.69897
Match: 1vfyA_
Description: vps27p protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 4.23430630035276 bayes_pls_golite062009
binding 2.35694469334775 bayes_pls_golite062009
phosphoinositide binding 1.5307798253901 bayes_pls_golite062009
protein binding 1.44642175542767 bayes_pls_golite062009
phospholipid binding 1.34712325037196 bayes_pls_golite062009
transporter activity 1.32696426532114 bayes_pls_golite062009
ADP-ribosylation factor binding 1.08699679453397 bayes_pls_golite062009
protein transporter activity 1.00558105390757 bayes_pls_golite062009
substrate-specific transporter activity 0.934511830388366 bayes_pls_golite062009
histone binding 0.75399983087006 bayes_pls_golite062009
phosphatidylinositol binding 0.67214549237381 bayes_pls_golite062009
lipid binding 0.131242568396849 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0347989334053008 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [308-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLSGIFAKY DSMQNISKVI DSLLPIFEDS LNSLKVETAK DSENTLDPKN LNDLARLRHK  60
   61 LLNSFNLYNT LTRQLLSVEP QSHLERQLQN SIKIASAAYI NEKILPLKSL PAILNPEGHK 120
  121 TNEDGQKAEP EVKKLSQLMI ENLTIKEVKE LREELMVLKE QSYLIESTIQ DYKKQRRLEE 180
  181 IVTLNKNLEE LHSRIHTVQS KLGDHGFN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle