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Protein Overview: DIN7

General Information:
Name(s) found: DIN7 / YDR263C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 430 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: DNA repair [IDALink to PubMed article][ISSLink to PubMed article]
    Molecular Function: nuclease activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIPGLLPQL KRIQKQVSLK KYMYQTLAID GYAWLHRASC ACAFELVMNK PTNKYLQFFI  60
   61 KRLQLLKRLK IKPYIVFDGD SLFVKNHTET RRRKKRLENE MIAKKLWSAG NRYNAMEYFQ 120
  121 KSVDITPEMA KCIIDYCKLH SIPYIVAPFE ADPQMVYLEK MGLIQGIISE DSDLLVFGCK 180
  181 TLITKLNDQG KALEISKDDF SALPENFPLG ELSEQQFRNL VCLAGCDYTS GIWKVGVVTA 240
  241 MKIVKRYSEM KDILIQIERT EKLCFSKAFK QQVEFANYAF QYQRVFCPLS NQITTLNNIP 300
  301 KAVTNSHAEI IKIMKCIGSV VERGSGVRKD VINTKNIDHK VHEMIAKGEL HPVDMASKLI 360
  361 NRERKLKARK LFKVGLLGGE SNSFNKKVEQ PLVDTQDVLS ERENSLDNKN ASSIYMTSPA 420
  421 AISGTVPSIF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DIN7 TDA1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPT21 DIN7 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..349] PSI-BLAST 164.0103 Flap endonuclease-1 (Fen-1 nuclease)
    2 View Details [350..430] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • flap endonuclease activity
    		•  3.67578601858151 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.29138075959109 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.25110450559975 bayes_pls_golite062009
  • exonuclease activity
    		•  3.08589196968812 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  2.82147159438565 bayes_pls_golite062009
  • nuclease activity
    		•  2.11339581411994 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  2.0005433655378 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.9833086883205 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.91303769651266 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  1.87664153967776 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  1.68933217523176 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.6357876066979 bayes_pls_golite062009
  • hydrolase activity
    		•  1.55146225298048 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.44561869581238 bayes_pls_golite062009
  • endonuclease activity
    		•  1.40552749109921 bayes_pls_golite062009
  • catalytic activity
    		•  1.37534898662234 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  1.27080587821961 bayes_pls_golite062009
  • DNA binding
    		•  1.0824699122398 bayes_pls_golite062009
  • binding
    		•  1.04616076007281 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.03274122519509 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.98172679437643 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  0.807459896574807 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.71603644615457 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.620251812982006 bayes_pls_golite062009
  • protein binding
    		•  0.236485289446406 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle