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Protein Overview: EBS1

General Information:
Name(s) found: EBS1 / YDR206W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 884 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    telomere maintenance via telomerase [IGILink to PubMed article][IMPLink to PubMed article]
    negative regulation of translation [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPSNTQKED LPTAFNGIKS QLNSILKSNQ LFQDYALLNG FLAFVHSKLN AAILTSIESQ  60
   61 CGKSFAADLD SFDQSSISSI LDFSWESVHY PIFKWFQMWR NYILFEKENK KQQTKFIDFR 120
  121 KMNSKMLKFF KTVQNFYVNV INTVYKKYDI SVLLPKRIIQ DLKLSDIENT TNVGDILAVK 180
  181 TFNSSSPLAH LIPTLFHRCL LFLGTAYRYK TLLEEISNKY SISNFKKSLD FFRLASLVLP 240
  241 SAGETYSQAG AIFLQTGNLG IAVFNFVKGM MTKMPSPVSI KNFGALMVDN KSSLNRSLHT 300
  301 TIMNTYLQES KGPRTPAKEI LEFYFLGLFG SVWSPTSWRD DTKPNQLNNG IKLRHLENAL 360
  361 YETMSARYLN NIKTIFHNLI ITIGGFHLLL KRRSDVSAKT LKDLRSNELD YLNFAFKYIA 420
  421 HILNDIVKES WSENPEVSEI LGMVRIINCW IKANPMVLQY SQSNLEFVNA LAYLINDIVK 480
  481 KKPSPSFSIT EHIPKRTYWF EEDLMVKGLS FVNFQLSDFD DYEKILEMDH SLDRLIGNPP 540
  541 LCDKLSASSE MLLRLQAVVN ISSQLLQNNN CGVEWSDNKS RYIFNKKIGF KETVKNSMKT 600
  601 SKQSNEKAKL QRKNKPSTTN GSISMADLER QMRSSSLDSF SPTMGYSGSS VPMAPDTFNV 660
  661 KPSGTITGNK VNVELLKIEL SGQNADGAIT NISPGYSNAA ISSSNSTDES SFDLNNILSS 720
  721 MQQKHAEKSF AKSMQGVNEQ IPANDVCHQA QRPMQGGLYS SQQPSSMSSL NSAYQNASMP 780
  781 PSASMVSYPY PFLNQQGQGV FPPYNAQNLQ WQSEAYSLKS MNFANPTWLG DQYQTSAPSS 840
  841 AYAQAQRQMF QQPMQQDVGK YMQFPFDAQS NTDSMRGNSR NNMF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] ORFEUS 7.29 Transcription factor MalT domain III
    2 View Details [81..264] ORFEUS 7.29 Transcription factor MalT domain III
    3 View Details [265..480] ORFEUS 7.29 Transcription factor MalT domain III
    4 View Details [481..884] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  2.76684454218635 bayes_pls_golite062009
  • binding
    		•  2.71974493738804 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.96129657517284 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.62783430593918 bayes_pls_golite062009
  • DNA binding
    		•  1.62663906748938 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.16294866757073 bayes_pls_golite062009
  • transcription factor activity
    		•  0.934706586922936 bayes_pls_golite062009
  • hydrolase activity
    		•  0.488980079329603 bayes_pls_golite062009
  • transcription factor binding
    		•  0.441518464573089 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.19094857768269 bayes_pls_golite062009
  • ligase activity
    		•  0.102007806594868 bayes_pls_golite062009
  • signal sequence binding
    		•  0.0231142793406351 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle