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Protein Overview: MKC7

General Information:
Name(s) found: MKC7 / YDR144C [SGD]
Description(s) found:
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  • gi|6320348|ref|NP_010428.1| GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p; Mkc7p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|56757623|sp|P53379.2|MKC7_YEAST RecName: Full=Aspartic proteinase MKC7; AltName: Full=Yapsin-2; Flags: Precursor [NCBI NR]
  • pir||S57971 aspartic proteinase MKC7 (EC 3.4.23.-) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Aspartic proteinase MKC7 OS=Saccharomyces cerevisiae GN=MKC7 PE=1 SV=2 [Swiss-Prot]
  • MKC7 Aspartyl protease of the periplasmic space [mips]
  • GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p [SGD]
  • MKC7, Chr IV from 744304-746094, reverse complement [yeast_orfs2]
  • Chr IV from 744304-746094, reverse complement [yeastorf3.fasta]
  • Chr IV from 746094-744304, reverse complement [yeastorf5.fasta]
  • MKC7 SGDID:S0002551, Chr IV from 746095-744305, reverse complement, Verified ORF [yeastflysequest.fasta]
  • MKC7 SGDID:S0002551, Chr IV from 746096-744306, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Mkc7p [Saccharomyces cerevisiae]gi|2132342|pir||S57971 aspartic proteinase MKC7 (EC 3.4.23.-) - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • MKC7 SGDID:S000002551, Chr IV from 746096-744306, reverse complement, Verified ORF, "GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MKC7 SGDID:S000002551, Chr IV from 746098-744308, reverse complement, Verified ORF, "GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p" [yeast-contam.fasta]
  • MKC7 SGDID:S000002551, Chr IV from 746099-744309, reverse complement, Verified ORF, "GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p; Mkc7p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Aspartic proteinase MKC7 precursor (Yapsin-2) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Aspartic proteinase MKC7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MKC7 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MKC7 SGDID:S000002551, Chr IV from 746101-744311, Genome Release 64-1-1, reverse complement, Verified ORF, "GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p" [yeast-030211-contam.fasta]
  • MKC7 SGDID:S000002551, Chr IV from 746101-744311, Genome Release 64-2-1, reverse complement, Verified ORF, "GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDR144C SGDID:S000002551, Chr IV from 746101-744311, Genome Release 64-1-1, reverse complement, Verified ORF, "GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 596 amino acids

    Gene Ontology:
    Cellular Component: fungal-type cell wall [IDALink to PubMed article]
    Biological Process: proteolysis [IMPLink to PubMed article]
    Molecular Function: aspartic-type signal peptidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSVLTFVV DALLVCSSIV DAGVTDFPSL PSNEVYVKMN FQKKYGSSFE NALDDTKGRT  60
   61 RLMTRDDDYE LVELTNQNSF YSVELDIGTP PQKVTVLVDT GSSDLWVTGS DNPYCSTKKK 120
  121 DTTGSSFKQV NKDALASVVE SVFTEISYDT TIVTSEATAT FDSTASTSQL IDCATYGTFN 180
  181 TSKSSTFNSN NTEFSIAYGD TTFASGTWGH DQLSLNDLNI TGLSFAVANE TNSTVGVLGI 240
  241 GLPGLESTYS GVSLSSVQKS YTYNNFPMVL KNSGVIKSTA YSLFANDSDS KHGTILFGAV 300
  301 DHGKYAGDLY TIPIINTLQH RGYKDPIQFQ VTLQGLGTSK GDKEDNLTTL TTTKIPVLLD 360
  361 SGTTISYMPT ELVKMLADQV GATYSSAYGY YIMDCIKEME EESSIIFDFG GFYLSNWLSD 420
  421 FQLVTDSRSN ICILGIAPQS DPTIILGDNF LANTYVVYDL DNMEISMAQA NFSDDGEYIE 480
  481 IIESAVPSAL KAPGYSSTWS TYESIVSGGN MFSTAANSSI SYFASTSHSA TSSSSSKGQK 540
  541 TQTSTTALSI SKSTSSTSST GMLSPTSSSS TRKENGGHNL NPPFFARFIT AIFHHI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RRB1 MKC7 1 Unpublished Fields Lab Data
    View Screen PSE1 MKC7 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MKC7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] PSI-BLAST 75.512579 No description for 1lcgA_ was found.
    2 View Details [145..276] PSI-BLAST 800.927757 No description for 1ypsA_ was found.
    3 View Details [277..313]
    [453..495]    		 PSI-BLAST 800.927757 No description for 1ypsA_ was found.
    4 View Details [314..452] PSI-BLAST 800.927757 No description for 1ypsA_ was found.
    5 View Details [496..596] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • aspartic-type endopeptidase activity
    		•  7.28637514153772 bayes_pls_golite062009
  • aspartic-type peptidase activity
    		•  7.28637514153772 bayes_pls_golite062009
  • peptidase activity
    		•  5.78181196721293 bayes_pls_golite062009
  • endopeptidase activity
    		•  5.4888481808613 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  5.39972232367526 bayes_pls_golite062009
  • hydrolase activity
    		•  3.97352810629953 bayes_pls_golite062009
  • catalytic activity
    		•  1.54514410489082 bayes_pls_golite062009
  • binding
    		•  0.902062095182608 bayes_pls_golite062009
  • receptor binding
    		•  0.772960860414817 bayes_pls_golite062009
  • drug binding
    		•  0.177583989372323 bayes_pls_golite062009
  • protein binding
    		•  0.094081389440774 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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