Protein Overview: MKC7

General Information:
Name(s) found:	MKC7 / YDR144C [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	596 amino acids
Gene Ontology:
Cellular Component:	fungal-type cell wall [IDA]
Biological Process:	proteolysis [IMP]
Molecular Function:	aspartic-type signal peptidase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSVLTFVV DALLVCSSIV DAGVTDFPSL PSNEVYVKMN FQKKYGSSFE NALDDTKGRT  60
   61 RLMTRDDDYE LVELTNQNSF YSVELDIGTP PQKVTVLVDT GSSDLWVTGS DNPYCSTKKK 120
  121 DTTGSSFKQV NKDALASVVE SVFTEISYDT TIVTSEATAT FDSTASTSQL IDCATYGTFN 180
  181 TSKSSTFNSN NTEFSIAYGD TTFASGTWGH DQLSLNDLNI TGLSFAVANE TNSTVGVLGI 240
  241 GLPGLESTYS GVSLSSVQKS YTYNNFPMVL KNSGVIKSTA YSLFANDSDS KHGTILFGAV 300
  301 DHGKYAGDLY TIPIINTLQH RGYKDPIQFQ VTLQGLGTSK GDKEDNLTTL TTTKIPVLLD 360
  361 SGTTISYMPT ELVKMLADQV GATYSSAYGY YIMDCIKEME EESSIIFDFG GFYLSNWLSD 420
  421 FQLVTDSRSN ICILGIAPQS DPTIILGDNF LANTYVVYDL DNMEISMAQA NFSDDGEYIE 480
  481 IIESAVPSAL KAPGYSSTWS TYESIVSGGN MFSTAANSSI SYFASTSHSA TSSSSSKGQK 540
  541 TQTSTTALSI SKSTSSTSST GMLSPTSSSS TRKENGGHNL NPPFFARFIT AIFHHI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#13 Mitotic Prep2-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	MKC7	Huh WK, et al. (2003)

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
aspartic-type endopeptidase activity	7.28637514153772	bayes_pls_golite062009
aspartic-type peptidase activity	7.28637514153772	bayes_pls_golite062009
peptidase activity	5.78181196721293	bayes_pls_golite062009
endopeptidase activity	5.4888481808613	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	5.39972232367526	bayes_pls_golite062009
hydrolase activity	3.97352810629953	bayes_pls_golite062009
catalytic activity	1.54514410489082	bayes_pls_golite062009
binding	0.902062095182608	bayes_pls_golite062009
receptor binding	0.772960860414817	bayes_pls_golite062009
drug binding	0.177583989372323	bayes_pls_golite062009
protein binding	0.094081389440774	bayes_pls_golite062009

No functions predicted.

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..144]	PSI-BLAST	75.512579	No description for 1lcgA_ was found.
2	View Details	[145..276]	PSI-BLAST	800.927757	No description for 1ypsA_ was found.
3	View Details	[277..313] [453..495]	PSI-BLAST	800.927757	No description for 1ypsA_ was found.
4	View Details	[314..452]	PSI-BLAST	800.927757	No description for 1ypsA_ was found.
5	View Details	[496..596]	deduced	N/A	No confident structure predictions are available.

Protein Overview: MKC7

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: