Protein Overview: DLD1

General Information:
Name(s) found:	DLD1 / YDL174C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6320027\|ref\|NP_010107.1\| D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; Dld1p [Saccharomyces cerevisiae [NCBI NR] gi\|2506961\|sp\|P32891.2\|DLD1_YEAST RecName: Full=D-lactate dehydrogenase [cytochrome] 1, mitochondrial; AltName: Full=D-lactate ferricytochrome C oxidoreductase; Short=D-LCR; Flags: Precursor [NCBI NR] pir\|\|S61038 D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1431279\|emb\|CAA98748.1\| DLD1 [Saccharomyces cerevisiae] [NCBI NR] gi\|1061264\|emb\|CAA91571.1\| D-lactate dehydrogenase [Saccharomyces cerevisiae] [NCBI NR] D-lactate dehydrogenase [cytochrome] 1, mitochondrial OS=Saccharomyces cerevisiae GN=DLD1 PE=1 SV=2 [Swiss-Prot] DLD1 D-lactate ferricytochrome C oxidoreductase (D-LCR) [mips] D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane [SGD] DLD1, Chr IV from 145827-147590, reverse complement [yeast_orfs2] Chr IV from 145827-147590, reverse complement [yeastorf3.fasta] Chr IV from 147590-145827, reverse complement [yeastorf5.fasta] (P32891) D-lactate dehydrogenase [cytochrome], mitochondrial precursor (EC 1.1.2.4) (D-lactate ferricytochrome C oxidoreductase) (D-LCR) [4932.FASTACCERV.txt] DLD1 SGDID:S0002333, Chr IV from 147590-145827, reverse complement, Verified ORF [yeastflysequest.fasta] D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane [Saccharomyces cerevisiae]gi\|1431279\|emb\|CAA98748.1\| DLD1 [ [nrdb_11152004_Chlamydomonas] DLD1 SGDID:S000002333, Chr IV from 147590-145827, reverse complement, Verified ORF, "D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mito [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] D-lactate dehydrogenase [cytochrome] 1, mitochondrial precursor (D-lactate ferricytochrome C oxidoreductase) (D-LCR) [nr-271106-contam.fasta] D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; Dld1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] D-lactate dehydrogenase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] DLD1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] DLD1 SGDID:S000002333, Chr IV from 147590-145827, reverse complement, Verified ORF, "D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane" [yeast-bovrabprots.fasta] [chemostatdb.fasta] D-lactate dehydrogenase [cytochrome] 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DLD1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] DLD1 SGDID:S000002333, Chr IV from 147589-145826, Genome Release 64-1-1, reverse complement, Verified ORF, "D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane" [yeast-030211-contam.fasta] DLD1 SGDID:S000002333, Chr IV from 147589-145826, Genome Release 64-2-1, reverse complement, Verified ORF, "D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane" [20141208_orf_trans.fasta] TR3660\|c0_g1_i1\|g.2517 ORF TR3660\|c0_g1_i1\|g.2517 TR3660\|c0_g1_i1\|m.2517 type:complete len:588 (+) TR3660\|c0_g1_i1:171-1934(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YDL174C SGDID:S000002333, Chr IV from 147589-145826, Genome Release 64-1-1, reverse complement, Verified ORF, "D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_1121\|g.723 ORF ID=asmbl_1121\|g.723 ID=asmbl_1121\|m.723 type:complete len:588 (+) ID=asmbl_1121:126-1889(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	587 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial inner membrane [IDA]
Biological Process:	carbohydrate metabolic process [IMP] aerobic respiration [IMP]
Molecular Function:	D-lactate dehydrogenase (cytochrome) activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLWKRTCTRL IKPIAQPRGR LVRRSCYRYA STGTGSTDSS SQWLKYSVIA SSATLFGYLF  60
   61 AKNLYSRETK EDLIEKLEMV KKIDPVNSTL KLSSLDSPDY LHDPVKIDKV VEDLKQVLGN 120
  121 KPENYSDAKS DLDAHSDTYF NTHHPSPEQR PRIILFPHTT EEVSKILKIC HDNNMPVVPF 180
  181 SGGTSLEGHF LPTRIGDTIT VDLSKFMNNV VKFDKLDLDI TVQAGLPWED LNDYLSDHGL 240
  241 MFGCDPGPGA QIGGCIANSC SGTNAYRYGT MKENIINMTI VLPDGTIVKT KKRPRKSSAG 300
  301 YNLNGLFVGS EGTLGIVTEA TVKCHVKPKA ETVAVVSFDT IKDAAACASN LTQSGIHLNA 360
  361 MELLDENMMK LINASESTDR CDWVEKPTMF FKIGGRSPNI VNALVDEVKA VAQLNHCNSF 420
  421 QFAKDDDEKL ELWEARKVAL WSVLDADKSK DKSAKIWTTD VAVPVSQFDK VIHETKKDMQ 480
  481 ASKLINAIVG HAGDGNFHAF IVYRTPEEHE TCSQLVDRMV KRALNAEGTC TGEHGVGIGK 540
  541 REYLLEELGE APVDLMRKIK LAIDPKRIMN PDKIFKTDPN EPANDYR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
View Details	Qiu et al. (2008)		CYB2 DLD1 GUT2 QCR8

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	DLD1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..100]	deduced	N/A	No confident structure predictions are available.
2	View Details	[101..327] [535..587]	PSI-BLAST	105.69897	Flavoprotein subunit of p-cresol methylhydroxylase
3	View Details	[328..534]	PSI-BLAST	105.69897	Flavoprotein subunit of p-cresol methylhydroxylase

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.89

Protein Overview: DLD1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: