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Protein Overview: SRP14

General Information:
Name(s) found: SRP14 / YDL092W [SGD]
Description(s) found:
Found 33 descriptions.
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  • Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 146 amino acids

    Gene Ontology:
    Cellular Component: signal recognition particle, endoplasmic reticulum targeting [IDALink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [ICLink to PubMed article]
    protein targeting to ER [IPILink to PubMed article]
    Molecular Function: signal sequence binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANTGCLSPG AFLSKVPEFF QTANEKHITV RLTAKRLIEH DPVEGNLEFD STNHPDYDVS  60
   61 KKASEISVSS RSDREYPLLI RMSYGSHDKK TKCSTVVKAS ELDQFWQEYS SVFKGGMQNL 120
  121 IKKKKKKSKN GTISKTGKKN KVAKKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details (MIPS) Mewes HW, et al. (2004) SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details Krogan NJ, et al. (2006) LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72 YCR090C
    View Details Gavin AC, et al. (2006) SEC65 SRP14 SRP54 SRP68 SRP72
    View Details Gavin AC, et al. (2002) BEM2 LHP1 SEC65 SRO9 SRP14 SRP21 SRP54 SRP68 SRP72
    View Details Qiu et al. (2008) SEC65 SRP14 SRP21 SRP54 SRP68 SRP72

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SRP14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..146] ORFEUS 8.64 Signal recognition particle 14KDa protein, SRP14


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle