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Protein Overview: NGR1

General Information:
Name(s) found: NGR1 / YBR212W [SGD]
Description(s) found:
Found 25 descriptions.
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  • RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 672 amino acids

    Gene Ontology:
    Cellular Component: perinuclear region of cytoplasm [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    cytoplasmic mRNA processing body [IDALink to PubMed article]
    Biological Process: regulation of growth [IMPLink to PubMed article]
    mitochondrion organization [IMPLink to PubMed article]
    Molecular Function: translation regulator activity [IMPLink to PubMed article]
    RNA binding [IDALink to PubMed articleLink to PubMed article]
    single-stranded DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSNVANASQ RQENPYIIPL PPSSTVETST EPPRTLWMGD LDPSFDEATI EEIWSKLDKK  60
   61 VIVKLIRAKK NLLIPCSSTS SSNNNTSEEN AENQQSASNS TDQLDNSQMI NINGISFIDP 120
  121 STTQLHHAGY CFVEFETQKD AKFALSLNAT PLPNFYSPTT NSQTNPTFKR TFRLNWASGA 180
  181 TLQSSIPSTP EFSLFVGDLS PTATEADLLS LFQTRFKSVK TVRVMTDPLT GSSRCFGFVR 240
  241 FGDEDERRRA LIEMSGKWFQ GRALRVAYAT PRNNMMLQLQ EQQQQQQQLQ QQHQQLDQED 300
  301 NNGPLLIKTA NNLIQNNSNM LPLNALHNAP PMHLNEGGIS NMRVNDSLPS NTYNTDPTNT 360
  361 TVFVGGLVPK TTEFQLRSLF KPFGPILNVR IPNGKNCGFV KFEKRIDAEA SIQGLQGFIV 420
  421 GGSPIRLSWG RPSSSNAKTN STIMGASQYM SSNGLRAPSA ASSVDNSKQI LEQYAEDKRR 480
  481 LFLHQQQQQQ QQQQQDGNFS MEQMAHNNYY NYNNYDYHRN KNGSHSDLVN LQRSNVPYMQ 540
  541 EDGALYPHQY SSPSYSLHPT GNQFSNATNN LPQFGNAMSI SMQLPNGNSN KTASSMNTNP 600
  601 NTNMIMNSNM NMNMNVNPVP YGMGNGANMY DVSRMMTPPL NIAPNSNNSK SSIMNKHPNR 660
  661 NNVPPIHPSL LH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HYR1 NGR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NGR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] PSI-BLAST 92.54902 Poly(A)-binding protein
    2 View Details [87..184] PSI-BLAST 89.28043 Hu antigen D (Hud)
    3 View Details [185..306] PSI-BLAST 89.28043 Hu antigen D (Hud)
    4 View Details [307..358] deduced N/A No confident structure predictions are available.
    5 View Details [359..475] PSI-BLAST 13.221849 CBP20, 20KDa nuclear cap-binding protein
    6 View Details [476..584] deduced N/A No confident structure predictions are available.
    7 View Details [585..672] PSI-BLAST 11.0 poly(A) binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  3.27266833016156 bayes_pls_golite062009
  • binding
    		•  2.80563734517858 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.18035791990719 bayes_pls_golite062009
  • mRNA binding
    		•  2.17710836425586 bayes_pls_golite062009
  • protein binding
    		•  1.02232785292059 bayes_pls_golite062009
    		• 0.787367154319901 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.419268956417989 bayes_pls_golite062009
  • structural molecule activity
    		•  0.106871867442361 bayes_pls_golite062009
    2
    Term Confidence Notes
  • RNA binding
    		•  3.27266833016156 bayes_pls_golite062009
  • binding
    		•  2.80563734517858 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.18035791990719 bayes_pls_golite062009
  • mRNA binding
    		•  2.17710836425586 bayes_pls_golite062009
  • protein binding
    		•  1.02232785292059 bayes_pls_golite062009
    		• 0.787367154319901 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.419268956417989 bayes_pls_golite062009
  • structural molecule activity
    		•  0.106871867442361 bayes_pls_golite062009
    3
    Term Confidence Notes
  • RNA binding
    		•  3.27266833016156 bayes_pls_golite062009
  • binding
    		•  2.80563734517858 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.18035791990719 bayes_pls_golite062009
  • mRNA binding
    		•  2.17710836425586 bayes_pls_golite062009
  • protein binding
    		•  1.02232785292059 bayes_pls_golite062009
    		• 0.787367154319901 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.419268956417989 bayes_pls_golite062009
  • structural molecule activity
    		•  0.106871867442361 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle