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Protein Overview: HYR1

General Information:
Name(s) found: HYR1 / YIR037W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 163 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IPILink to PubMed article]
    Biological Process: response to oxidative stress [IMPLink to PubMed article]
    Molecular Function: phospholipid-hydroperoxide glutathione peroxidase activity [IDALink to PubMed article][IMPLink to PubMed article]
    glutathione peroxidase activity [IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    thioredoxin peroxidase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEFYKLAPV DKKGQPFPFD QLKGKVVLIV NVASKCGFTP QYKELEALYK RYKDEGFTII  60
   61 GFPCNQFGHQ EPGSDEEIAQ FCQLNYGVTF PIMKKIDVNG GNEDPVYKFL KSQKSGMLGL 120
  121 RGIKWNFEKF LVDKKGKVYE RYSSLTKPSS LSETIEELLK EVE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HYR1 NGR1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HYR1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..163] PSI-BLAST 220.502279 Glutathione peroxidase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle