Protein Overview: EXO84

General Information:
Name(s) found:	EXO84 / YBR102C [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis [SGD]
Organism:	Saccharomyces cerevisiae
Length:	753 amino acids
Gene Ontology:
Cellular Component:	incipient cellular bud site [IDA] cellular bud tip [IDA] cellular bud neck [IDA] exocyst [IPI]
Biological Process:	exocytosis [IGI][IMP][IPI] spliceosome assembly [IGI][IMP][IPI]
Molecular Function:	protein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEFSLKKAR NNWKHVKKSA SSPAKQKTPP SPAKPKQKTK KNPYSDLKDP ATSYTLPTIN  60
   61 ARERSRVATS MQRRLSIHNT NYAPPTLDYS MPLPDMPNMI VPNDNVDSSH NNSSFTTENE 120
  121 SVSSKGPSNS LNLSTADLSL NDSSYNKVPA RSAMRNTVNP SGSNDPFNNS TSLRKMLANP 180
  181 HFNAKDFVHD KLGNASAITI DKFTSNLTDL SIQVQEEVKL NINKSYNEIM TVNNDLNVAM 240
  241 LELKRVRANI NDLNEVLDQC TKIAEKRLQL QDQIDQERQG NFNNVESHSN SPALLPPLKA 300
  301 GQNGNLMRRD RSSVLILEKF WDTELDQLFK NVEGAQKFIN STKGRHILMN SANWMELNTT 360
  361 TGKPLQMVQI FILNDLVLIA DKSRDKQNDF IVSQCYPLKD VTVTQEEFST KRLLFKFSNS 420
  421 NSSLYECRDA DECSRLLDVI RKAKDDLCDI FHVEEENSKR IRESFRYLQS TQQTPGRENN 480
  481 RSPNKNKRRS MGGSITPGRN VTGAMDQYLL QNLTLSMHSR PRSRDMSSTA QRLKFLDEGV 540
  541 EEIDIELARL RFESAVETLL DIESQLEDLS ERISDEELML LNLISLKIEQ RREAISSKLS 600
  601 QSILSSNEIV HLKSGTENMI KLGLPEQALD LFLQNRSNFI QDLILQIGSV DNPTNYLTQL 660
  661 AVIRFQTIKK TVEDFQDIFK ELGAKISSIL VDWCSDEVDN HFKLIDKQLL NDEMLSPGSI 720
  721 KSSRKQIDGL KAVGLDFVYK LDEFIKKNSD KIR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		EXO84 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8
View Details	Gavin AC, et al. (2006)		EXO84 SEC10 SEC3 SEC5 SEC6 SEC8
View Details	Gavin AC, et al. (2002)		EXO84 SEC10 SEC3 SEC5 SEC6 SEC8 VPS9
View Details	Qiu et al. (2008)		EXO70 EXO84 SEC10 SEC15 SEC3 SEC5 SEC6 SEC8

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	SEC10	No Comments	De Craene, J., et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	EXO84	SEC15	2	Drees BL, et al. (2001)
View Screen	EXO84	TRM112	2	Unpublished Fields Lab Data
View Screen	PCF11	EXO84	1	Unpublished Fields Lab Data
View Screen	IRE1	EXO84	1	Unpublished Fields Lab Data
View Screen	SPP382	EXO84	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	EXO84	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..157]	deduced	N/A	No confident structure predictions are available.
2	View Details	[158..279]	MSA	1.015997	View MSA. Confident ab initio structure predictions are available.
3	View Details	[280..341]	deduced	N/A	No confident structure predictions are available.
4	View Details	[342..480]	PSI-BLAST	3.09691	Son of sevenless-1 (sos-1)
5	View Details	[481..753]	MSA	4.017997	View MSA. No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2