Protein Overview: UGA2

General Information:
Name(s) found:	UGA2 / YBR006W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319478\|ref\|NP_009560.1\| Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm; Uga2p [Saccharomyc [NCBI NR] gi\|6136604\|sp\|P38067.2\|UGA2_YEAST RecName: Full=Succinate-semialdehyde dehydrogenase [NADP+]; Short=SSDH [NCBI NR] gi\|4388565\|emb\|CAA84943.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Succinate-semialdehyde dehydrogenase [NADP+] OS=Saccharomyces cerevisiae GN=UGA2 PE=1 SV=2 [Swiss-Prot] UGA2 Succinate semialdehyde dehydrogenase [mips] Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm [SGD] UGA2, Chr II from 246971-248464 [yeast_orfs2] Chr II from 246971-248464 [yeastorf3.fasta] (P38067) Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16) (SSDH) [4932.FASTACCERV.txt] UGA2 SGDID:S0000210, Chr II from 246974-248467, Verified ORF [yeastflysequest.fasta] UGA2 SGDID:S0000210, Chr II from 247012-248505, Verified ORF [10112005cervSGD.fasta] Uga2p [Saccharomyces cerevisiae]gi\|4388565\|emb\|CAA84943.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|6136604\|sp\|P38067\|UGA2_YEAST Succinate-semialdehyde dehydrogenase [NADP+] (SSDH) [nrdb_11152004_Chlamydomonas] UGA2 SGDID:S000000210, Chr II from 247012-248505, Verified ORF, "Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm; Uga2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Succinate-semialdehyde dehydrogenase [NADP+] (SSDH) [nr-271106-contam.fasta] UGA2 SGDID:S000000210, Chr II from 247012-248505, Verified ORF, "Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Succinate-semialdehyde dehydrogenase [NADP(+)] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UGA2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] UGA2 SGDID:S000000210, Chr II from 247010-248503, Genome Release 64-1-1, Verified ORF, "Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm" [yeast-030211-contam.fasta] UGA2 SGDID:S000000210, Chr II from 247010-248503, Genome Release 64-2-1, Verified ORF, "Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm" [20141208_orf_trans.fasta] TR7162\|c0_g1_i1\|g.5000 ORF TR7162\|c0_g1_i1\|g.5000 TR7162\|c0_g1_i1\|m.5000 type:complete len:498 (+) TR7162\|c0_g1_i1:136-1629(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YBR006W SGDID:S000000210, Chr II from 247010-248503, Genome Release 64-1-1, Verified ORF, "Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_4608\|g.2862 ORF ID=asmbl_4608\|g.2862 ID=asmbl_4608\|m.2862 type:complete len:498 (+) ID=asmbl_4608:132-1625(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	497 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	response to oxidative stress [IEP][IMP] gamma-aminobutyric acid catabolic process [IEP][IMP][ISS] glutamate decarboxylation to succinate [IGI][IMP][ISS]
Molecular Function:	succinate-semialdehyde dehydrogenase [NAD(P)+] activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLSKYSKPT LNDPNLFRES GYIDGKWVKG TDEVFEVVDP ASGEIIARVP EQPVSVVEEA  60
   61 IDVAYETFKT YKNTTPRERA KWLRNMYNLM LENLDDLATI ITLENGKALG EAKGEIKYAA 120
  121 SYFEWYAEEA PRLYGATIQP LNPHNRVFTI RQPVGVCGII CPWNFPSAMI TRKAAAALAV 180
  181 GCTVVIKPDS QTPLSALAMA YLAEKAGFPK GSFNVILSHA NTPKLGKTLC ESPKVKKVTF 240
  241 TGSTNVGKIL MKQSSSTLKK LSFELGGNAP FIVFEDADLD QALEQAMACK FRGLGQTCVC 300
  301 ANRLYVHSSI IDKFAKLLAE RVKKFVIGHG LDPKTTHGCV INSSAIEKVE RHKQDAIDKG 360
  361 AKVVLEGGRL TELGPNFYAP VILSHVPSTA IVSKEETFGP LCPIFSFDTM EEVVGYANDT 420
  421 EFGLAAYVFS KNVNTLYTVS EALETGMVSC NTGVFSDCSI PFGGVKESGF GREGSLYGIE 480
  481 DYTVLKTITI GNLPNSI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	None Entered	#17 Mitotic Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC48	UGA2	1	Unpublished Fields Lab Data
View Screen	GAL7	UGA2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	UGA2	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..265] [464..497]	PSI-BLAST	1805.228787	Aldehyde reductase (dehydrogenase), ALDH
2	View Details	[266..463]	PSI-BLAST	1805.228787	Aldehyde reductase (dehydrogenase), ALDH

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors	5.09598561374689	bayes_pls_golite062009
oxidoreductase activity	4.47226217021998	bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity	4.35175408702761	bayes_pls_golite062009
malonate-semialdehyde dehydrogenase (acetylating) activity	4.2273960318884	bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity	3.87605237828483	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity	3.64672165191647	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	3.37049090049734	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3.2867555127991	bayes_pls_golite062009
glutamate-5-semialdehyde dehydrogenase activity	3.27180265380824	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.99564252244797	bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity	2.81851373615334	bayes_pls_golite062009
catalytic activity	2.80804701752928	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity	2.71501590413507	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors	2.70230501280821	bayes_pls_golite062009
aldehyde dehydrogenase [NAD(P)+] activity	2.43250909158896	bayes_pls_golite062009
aminobutyraldehyde dehydrogenase activity	2.35958138496479	bayes_pls_golite062009
acyl-CoA binding	2.26220696569489	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	1.6559690223037	bayes_pls_golite062009
retinal dehydrogenase activity	1.42867174920845	bayes_pls_golite062009
electron carrier activity	1.33390667257376	bayes_pls_golite062009
binding	1.06673666884196	bayes_pls_golite062009
retinoid binding	0.983782635681687	bayes_pls_golite062009
isoprenoid binding	0.900374761028287	bayes_pls_golite062009
protein binding	0.894945263794726	bayes_pls_golite062009
hydrolase activity	0.799513645745266	bayes_pls_golite062009
histidinol dehydrogenase activity	0.258030369394064	bayes_pls_golite062009
benzaldehyde dehydrogenase (NAD+) activity	0.23487570676521	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2