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Protein Overview: MDM10

General Information:
Name(s) found: MDM10 / YAL010C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial outer membrane [IDALink to PubMed article][TASLink to PubMed article]
    mitochondrial sorting and assembly machinery complex [IPILink to PubMed article]
    Biological Process: mitochondrion inheritance [TASLink to PubMed article]
    protein complex assembly [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    mitochondrion organization [TASLink to PubMed article]
    mitochondrial genome maintenance [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPYMDQVLR AFYQSTHWST QNSYEDITAT SRTLLDFRIP SAIHLQISNK STPNTFNSLD  60
   61 FSTRSRINGS LSYLYSDAQQ LEKFMRNSTD IPLQDATETY RQLQPNLNFS VSSANTLSSD 120
  121 NTTVDNDKKL LHDSKFVKKS LYYGRMYYPS SDLEAMIIKR LSPQTQFMLK GVSSFKESLN 180
  181 VLTCYFQRDS HRNLQEWIFS TSDLLCGYRV LHNFLTTPSK FNTSLYNNSS LSLGAEFWLG 240
  241 LVSLSPGCST TLRYYTHSTN TGRPLTLTLS WQPLFGHISS TYSAKTGTNS TFCAKYDFNL 300
  301 YSIESNLSFG CEFWQKKHHL LETNKNNNDK LEPISDELVD INPNSRATKL LHENVPDLNS 360
  361 AVNDIPSTLD IPVHKQKLLN DLTYAFSSSL RKIDEERSTI EKFDNKINSS IFTSVWKLST 420
  421 SLRDKTLKLL WEGKWRGFLI SAGTELVFTR GFQESLSDDE KNDNAISISA TDTENGNIPV 480
  481 FPAKFGIQFQ YST

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) MDM10 MPM1 RVB2 TOM40
    View Details Qiu et al. (2008) MDM10 SAM37

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIT2 MDM10 1 Unpublished Fields Lab Data
    View Screen YDL121C MDM10 1 Unpublished Fields Lab Data
    View Screen CDC4 MDM10 1 Unpublished Fields Lab Data
    View Screen CAB2 MDM10 1 Unpublished Fields Lab Data
    View Screen RAD1 MDM10 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MDM10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..326] MSA 2.004874 View MSA. No confident structure predictions are available.
    2 View Details [327..493] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle