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Protein Overview: gi|85725020, gi|...

General Information:
Name(s) found: gi|85725020 [NCBI NR]
gi|84795754 [NCBI NR]
gi|62288210 [NCBI NR]
Description(s) found:
Found 7 descriptions.
SHOW ALL
  • gi|85725020|ref|NP_001033946.1| I[[h]] channel CG8585-PD, isoform D [Drosophila melanogaster] [NCBI NR]
  • gi|84795754|gb|ABC66060.1| CG8585-PD, isoform D [Drosophila melanogaster] [NCBI NR]
  • gi|62288210|gb|AAX78395.1| hyperpolarization-activated ion channel variant DMIH-A3B1C1 [Drosophila melanogaster] [NCBI NR]
    • Organism: Drosophila melanogaster
    Length: 627 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    plasma membrane [ISS]
    Biological Process: potassium ion transport [IEA]
    transmembrane transport [IEA]
    Molecular Function: voltage-gated potassium channel activity [IEA]
    voltage-gated ion channel activity [ISS][NAS]
    intracellular cyclic nucleotide activated cation channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLHSDPSMQ VHFDDVSLYG TPKEEPMPNI PIVSEKVSAN FLKSQLQSWF QPTDNRLAMK  60
   61 LFGSRKALVK ERIRQKTSGH WVIHPCSSFR FYWDLCMLLL LVANLIILPV AISFFNDDLS 120
  121 TRWIAFNCLS DTIFLIDIVV NFRTGIMQQD NAEQVILDPK LIAKHYLRTW FFLDLISSIP 180
  181 LDYIFLIFNQ DFSDSFQILH AGRALRILRL AKLLSLVRLL RLSRLVRYVS QWEEVYFLNM 240
  241 ASVFMRIFNL ICMMLLIGHW SGCLQFLVPM LQGFPSNSWV SINELQESYW LEQYSWALFK 300
  301 AMSHMLCIGY GRFPPQSLTD MWLTMLSMIS GATCYALFLG HATNLIQSLD SSRRQYREKV 360
  361 KQVEEYMAYR KLPRDMRQRI TEYFEHRYQG KFFDEELILG ELSEKLREDV INYNCRSLVA 420
  421 SVPFFANADS NFVSDVVTKL KYEVFQPGDI IIKEGTIGTK MYFIQEGVVD IVMANGEVAT 480
  481 SLSDGSYFGE ICLLTNARRV ASVRAETYCN LFSLSVDHFN CVLDQYPLMR KTMETVAAER 540
  541 LNKIGKNPNI MHQKDEQLSN PESNTITAVV NALAAEADDC KDDDMDLKEN LLHGSESSIA 600
  601 EPVQTIREGL PRPRSGEFRA LFEGNTP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..371] PSI-BLAST 34.69897 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [372..558] PSI-BLAST 22.0 HCN2J 443-645 in the presence of cGMP
    3 View Details [559..627] PSI-BLAST 12.09691 Crystal Structure of Transcriptional Regulator TTHA1359 form Thermus thermophilus HB8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • intracellular cyclic nucleotide activated cation channel activity
    		•  11.4016635726548 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  11.4016635726548 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  11.0380255638103 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ion channel activity
    		•  7.64606920655297 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  7.59395590157869 bayes_pls_golite062009
  • channel activity
    		•  7.59395590157869 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  7.57634767761298 bayes_pls_golite062009
  • cation channel activity
    		•  7.48229936274058 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.44819644778429 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.44819644778429 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • gated channel activity
    		•  7.35685244969057 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  7.0348537556435 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.72292819688752 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.69973028985609 bayes_pls_golite062009
  • potassium channel activity
    		•  3.23703259983923 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  2.92456251340287 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.92372539567194 bayes_pls_golite062009
  • transporter activity
    		•  2.8998330876169 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.89477800653409 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.8926771958768 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.85192191539872 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55771040353717 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.46282462455194 bayes_pls_golite062009
  • binding
    		•  1.14074551098763 bayes_pls_golite062009
  • protein binding
    		•  0.560659365968498 bayes_pls_golite062009
  • signal transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle