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View Structure Prediction Details

Protein: gi|85725020, gi|...
Organism: Drosophila melanogaster
Length: 627 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|85725020, gi|....

Description E-value Query
Range		 Subject
Range
Ih-PB - The gene I<down>h</down> channel is referred to in FlyBase by the symbol Dmel\Ih (CG8585, FBgn002842...
 372.0 [0..10] [627..673]

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Predicted Domain #1
Region A:
Residues: [1-371] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLHSDPSMQ VHFDDVSLYG TPKEEPMPNI PIVSEKVSAN FLKSQLQSWF QPTDNRLAMK  60
   61 LFGSRKALVK ERIRQKTSGH WVIHPCSSFR FYWDLCMLLL LVANLIILPV AISFFNDDLS 120
  121 TRWIAFNCLS DTIFLIDIVV NFRTGIMQQD NAEQVILDPK LIAKHYLRTW FFLDLISSIP 180
  181 LDYIFLIFNQ DFSDSFQILH AGRALRILRL AKLLSLVRLL RLSRLVRYVS QWEEVYFLNM 240
  241 ASVFMRIFNL ICMMLLIGHW SGCLQFLVPM LQGFPSNSWV SINELQESYW LEQYSWALFK 300
  301 AMSHMLCIGY GRFPPQSLTD MWLTMLSMIS GATCYALFLG HATNLIQSLD SSRRQYREKV 360
  361 KQVEEYMAYR K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.69897
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [372-558] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPRDMRQRIT EYFEHRYQGK FFDEELILGE LSEKLREDVI NYNCRSLVAS VPFFANADSN  60
   61 FVSDVVTKLK YEVFQPGDII IKEGTIGTKM YFIQEGVVDI VMANGEVATS LSDGSYFGEI 120
  121 CLLTNARRVA SVRAETYCNL FSLSVDHFNC VLDQYPLMRK TMETVAAERL NKIGKNPNIM 180
  181 HQKDEQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.0
Match: 1q3eA
Description: HCN2J 443-645 in the presence of cGMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
intracellular cyclic nucleotide activated cation channel activity 11.4016635726548 bayes_pls_golite062009
cyclic nucleotide-gated ion channel activity 11.4016635726548 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 11.0380255638103 bayes_pls_golite062009
intracellular cGMP activated cation channel activity 9.19973076787954 bayes_pls_golite062009
cGMP binding 7.7575871125398 bayes_pls_golite062009
ion channel activity 7.64606920655297 bayes_pls_golite062009
passive transmembrane transporter activity 7.59395590157869 bayes_pls_golite062009
channel activity 7.59395590157869 bayes_pls_golite062009
substrate-specific channel activity 7.57634767761298 bayes_pls_golite062009
cation channel activity 7.48229936274058 bayes_pls_golite062009
ligand-gated channel activity 7.44819644778429 bayes_pls_golite062009
ligand-gated ion channel activity 7.44819644778429 bayes_pls_golite062009
cyclic nucleotide binding 7.37322432929433 bayes_pls_golite062009
gated channel activity 7.35685244969057 bayes_pls_golite062009
metal ion transmembrane transporter activity 7.0348537556435 bayes_pls_golite062009
GMP binding 5.49455172024846 bayes_pls_golite062009
voltage-gated ion channel activity 4.72292819688752 bayes_pls_golite062009
voltage-gated channel activity 4.69973028985609 bayes_pls_golite062009
potassium channel activity 3.23703259983923 bayes_pls_golite062009
voltage-gated cation channel activity 2.92456251340287 bayes_pls_golite062009
substrate-specific transporter activity 2.92372539567194 bayes_pls_golite062009
transporter activity 2.8998330876169 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.89477800653409 bayes_pls_golite062009
ion transmembrane transporter activity 2.8926771958768 bayes_pls_golite062009
transmembrane transporter activity 2.85192191539872 bayes_pls_golite062009
cation transmembrane transporter activity 2.55771040353717 bayes_pls_golite062009
voltage-gated potassium channel activity 2.46282462455194 bayes_pls_golite062009
binding 1.14074551098763 bayes_pls_golite062009
protein binding 0.560659365968498 bayes_pls_golite062009
signal transducer activity 0.202809682876964 bayes_pls_golite062009
molecular transducer activity 0.202809682876964 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [559-627] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNPESNTITA VVNALAAEAD DCKDDDMDLK ENLLHGSESS IAEPVQTIRE GLPRPRSGEF  60
   61 RALFEGNTP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.09691
Match: 2cohA
Description: Crystal Structure of Transcriptional Regulator TTHA1359 form Thermus thermophilus HB8
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle