Protein Overview: SMC2

General Information:
Name(s) found:	SMC2 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|57997175\|emb\|CAI46187.1\| hypothetical protein [Homo sapiens] [NCBI NR] gi\|55958454\|emb\|CAI16923.1\| structural maintenance of chromosomes 2 [Homo sapiens] [NCBI NR] gi\|55957990\|emb\|CAI16866.1\| structural maintenance of chromosomes 2 [Homo sapiens] [NCBI NR] gi\|42627769\|tpe\|CAD89875.1\| TPA: SMC2 protein [Homo sapiens] [NCBI NR] gi\|215273886\|sp\|O95347.2\|SMC2_HUMAN RecName: Full=Structural maintenance of chromosomes protein 2; AltName: Full=Chromosome-associated protein E; Short=hCAP-E; AltName: Full=XCAP-E homolog [NCBI NR] gi\|120659846\|gb\|AAI30386.1\| Structural maintenance of chromosomes 2 [Homo sapiens] [NCBI NR] gi\|119579381\|gb\|EAW58977.1\| SMC2 structural maintenance of chromosomes 2-like 1 (yeast), isoform CRA_a [Homo sapiens] [NCBI NR] gi\|119579379\|gb\|EAW58975.1\| SMC2 structural maintenance of chromosomes 2-like 1 (yeast), isoform CRA_a [Homo sapiens] [NCBI NR] gi\|119579377\|gb\|EAW58973.1\| SMC2 structural maintenance of chromosomes 2-like 1 (yeast), isoform CRA_a [Homo sapiens] [NCBI NR] gi\|110347425\|ref\|NP_001036016.1\| structural maintenance of chromosomes 2 [Homo sapiens] [NCBI NR] gi\|110347420\|ref\|NP_001036015.1\| structural maintenance of chromosomes 2 [Homo sapiens] [NCBI NR] gi\|110347418\|ref\|NP_006435.2\| structural maintenance of chromosomes 2 [Homo sapiens] [NCBI NR] structural maintenance of chromosomes 2 [HGNC (HUGO)] Structural maintenance of chromosomes protein 2 OS=Homo sapiens GN=SMC2 PE=1 SV=2 [Swiss-Prot] TPA: SMC2 protein [Homo sapiens] [nrdb_11152004_Chlamydomonas] structural maintenance of chromosomes 2-like 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] structural maintenance of chromosomes 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Structural maintenance of chromosomes 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] SMC2 structural maintenance of chromosomes 2-like 1 (yeast), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] hypothetical protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=SMC2 Isoform 1 of Structural maintenance of chromosomes protein 2 [human-ipi-250309-contam.fasta] SMC2 structural maintenance of chromosomes 2-like 1 (yeast) [Homo sapiens] [nr-271106-contam.fasta] IPI:IPI00007927.4\|SWISS-PROT:O95347-1\|TREMBL:A8K984;B3KM27;B3KMB1;B7ZLZ7\|ENSEMBL:ENSP00000286398;ENSP00000363919;ENSP00000363925\|REFSEQ:NP_001036015;NP_001036016;NP_006435\|H-INV:HIT000068366\|VEGA:OTTHUMP00000021818;OTTHUMP00000021819 Tax_Id=9606 Gene_Symb [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] structural maintenance of chromosomes protein 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] O95347;Q6IEE0;Q9P1P2; RecName: Full=Structural maintenance of chromosomes protein 2; AltName: Full=Chromosome-associated protein E; AltName: Full=XCAP-E homolog; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of Structural maintenance of chromosomes protein 2 OS=Homo sapiens GN=SMC2 [011711_HMR.fasta] IPI:IPI00007927.4\|SWISS-PROT:O95347-1\|TREMBL:A8K984;B3KM27;B3KMB1;B7ZLZ7\|ENSEMBL:ENSP00000286398;ENSP00000363919;ENSP00000363925\|REFSEQ:NP_001036015;NP_001036016;NP_006435\|H-INV:HIT000068366\|VEGA:OTTHUMP00000021818;OTTHUMP00000021819 Tax_Id=9606 Gene_Symbol=SMC2 Isoform 1 of Structural maintenance of chromosomes protein 2 [ipi.HUMAN.fasta.20100406] GeneSymbol=SMC2 Synonyms=CAP-E\|CAPE\|FLJ10093\|SMC2L1\|hCAP-E structural maintenance of chromosomes protein 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] Structural maintenance of chromosomes protein 2 GN=SMC2 [Doctor+uniprot-HUMAN-120911.fasta] Structural maintenance of chromosomes protein OS=Homo sapiens GN=SMC2L1 PE=3 SV=1 [uniprot-human-031015-contam.fasta]
Organism:	Homo sapiens
Length:	1197 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS  60
   61 NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 120
  121 NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 180
  181 AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 240
  241 LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE 300
  301 DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH 360
  361 ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ 420
  421 MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE 480
  481 KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA 540
  541 LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP 600
  601 DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH 660
  661 GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE 720
  721 MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLENKM 780
  781 KNAEAERERE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL 840
  841 EAVNEAIKSY ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK 900
  901 EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ PNSAYDFKTN 960
  961 NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILTTIE1020
 1021 DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE1080
 1081 NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF1140
 1141 IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
DNA clamp loader activity	3.69872504333327	bayes_pls_golite062009
binding	3.21663307302451	bayes_pls_golite062009
motor activity	2.79327761685782	bayes_pls_golite062009
microtubule motor activity	2.74365461017633	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.69246499202248	bayes_pls_golite062009
pyrophosphatase activity	2.61582393123755	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.59641929642359	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.59333672868803	bayes_pls_golite062009
DNA-dependent ATPase activity	2.58390156971125	bayes_pls_golite062009
transporter activity	2.17383908004663	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
ATPase activity	2.11122403732968	bayes_pls_golite062009
transmembrane transporter activity	2.02444700826552	bayes_pls_golite062009
ATPase activity, coupled	1.8908019270286	bayes_pls_golite062009
DNA binding	1.72568209621547	bayes_pls_golite062009
transcription regulator activity	1.63193306273479	bayes_pls_golite062009
cytoskeletal protein binding	1.40488517180956	bayes_pls_golite062009
hydrolase activity	1.35268825531078	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
tubulin binding	0.979946830272106	bayes_pls_golite062009
substrate-specific transporter activity	0.97700154207756	bayes_pls_golite062009
microtubule binding	0.907162506177187	bayes_pls_golite062009
actin binding	0.883285269827407	bayes_pls_golite062009
purine nucleotide binding	0.725611289205392	bayes_pls_golite062009
nucleotide binding	0.717697610309727	bayes_pls_golite062009
purine ribonucleotide binding	0.713814218071151	bayes_pls_golite062009
ribonucleotide binding	0.713752628021599	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.654899784430321	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.608058786636536	bayes_pls_golite062009
transcription factor activity	0.567932466447757	bayes_pls_golite062009
kinetochore binding	0.534490088080411	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
centromeric DNA binding	0.322818640526369	bayes_pls_golite062009
DNA helicase activity	0.29158988711192	bayes_pls_golite062009
ATP binding	0.19169045543599	bayes_pls_golite062009
helicase activity	0.17080683362659	bayes_pls_golite062009
adenyl ribonucleotide binding	0.165732470448462	bayes_pls_golite062009
adenyl nucleotide binding	0.162060759063149	bayes_pls_golite062009
dynein binding	0.150959629961177	bayes_pls_golite062009
active transmembrane transporter activity	0.114463153989353	bayes_pls_golite062009
microfilament motor activity	0.10236059675512	bayes_pls_golite062009
ion transmembrane transporter activity	0.081265446432119	bayes_pls_golite062009
protein binding	0.071010918255742	bayes_pls_golite062009
recombinase activity	0.0490751527151101	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
binding	3.48985538444161	bayes_pls_golite062009
nucleic acid binding	1.85809295645854	bayes_pls_golite062009
DNA binding	1.71700314893388	bayes_pls_golite062009
protein binding	0.927138723776922	bayes_pls_golite062009
protein heterodimerization activity	0.558475595998159	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.299763949828861	bayes_pls_golite062009
DNA secondary structure binding	0.284996962785104	bayes_pls_golite062009
catalytic activity	0.265320175609019	bayes_pls_golite062009
pyrophosphatase activity	0.248383422632029	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.235472660839816	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.233111707634177	bayes_pls_golite062009
sequence-specific DNA binding	0.154578921841996	bayes_pls_golite062009
ATPase activity	0.08869715759545	bayes_pls_golite062009
protein dimerization activity	0.0245162068641336	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..173]	PSI-BLAST	40.522879	Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
2	View Details	[174..481]	FFAS03	2.27	No description for 2i1jA was found.
3	View Details	[482..697]	FFAS03	4.54	Smc hinge domain
4	View Details	[698..1026]	FFAS03	2.04	No description for 2oevA was found.
5	View Details	[1027..1197]	PSI-BLAST	18.221849	Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.

Protein Overview: SMC2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: