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View Structure Prediction Details

Protein: SMC2
Organism: Homo sapiens
Length: 1197 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMC2.

Description E-value Query
Range		 Subject
Range
gi|74208366 - gi|74208366|dbj|BAE26376.1| unnamed protein product [Mus musculus]
 1.0E-97 [1..1189] [1..1189]
gi|109476453 - gi|109476453|ref|XP_001053521.1| PREDICTED: similar to structural maintenance of chromosomes 2-like ...
 4.0E-95 [1..1187] [1..1187]
SMC2 - structural maintenance of chromosomes 2
 1.0E-93 [1..1197] [1..1197]
gi|58390664, gi|... - gi|58390664|ref|XP_317878.2| ENSANGP00000012139 [Anopheles gambiae str. PEST], gi|57913907|ref|XP_55...
gi|27227574 - gi|27227574|emb|CAD59404.1| SMC2 protein [Anopheles gambiae]
 1.0E-93 [1..1170] [1..1168]
gi|109110711, gi... - gi|109110711|ref|XP_001110295.1| PREDICTED: structural maintenance of chromosomes 2-like 1 isoform 6...
 1.0E-92 [1..1197] [1..1197]
gi|114625954, gi... - gi|114625954|ref|XP_001137448.1| PREDICTED: structural maintenance of chromosomes 2-like 1 isoform 1...
 1.0E-92 [1..1196] [1..1196]
gi|73971498 - gi|73971498|ref|XP_538759.2| PREDICTED: similar to Structural maintenance of chromosome 2-like 1 pro...
 2.0E-91 [1..1187] [1..1187]

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Predicted Domain #1
Region A:
Residues: [1-173] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS  60
   61 NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 120
  121 NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.522879
Match: 1xewX
Description: Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 3.69872504333327 bayes_pls_golite062009
binding 3.21663307302451 bayes_pls_golite062009
motor activity 2.79327761685782 bayes_pls_golite062009
microtubule motor activity 2.74365461017633 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.69246499202248 bayes_pls_golite062009
pyrophosphatase activity 2.61582393123755 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.59641929642359 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.59333672868803 bayes_pls_golite062009
DNA-dependent ATPase activity 2.58390156971125 bayes_pls_golite062009
transporter activity 2.17383908004663 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
ATPase activity 2.11122403732968 bayes_pls_golite062009
transmembrane transporter activity 2.02444700826552 bayes_pls_golite062009
ATPase activity, coupled 1.8908019270286 bayes_pls_golite062009
DNA binding 1.72568209621547 bayes_pls_golite062009
transcription regulator activity 1.63193306273479 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
hydrolase activity 1.35268825531078 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
tubulin binding 0.979946830272106 bayes_pls_golite062009
substrate-specific transporter activity 0.97700154207756 bayes_pls_golite062009
microtubule binding 0.907162506177187 bayes_pls_golite062009
actin binding 0.883285269827407 bayes_pls_golite062009
purine nucleotide binding 0.725611289205392 bayes_pls_golite062009
nucleotide binding 0.717697610309727 bayes_pls_golite062009
purine ribonucleotide binding 0.713814218071151 bayes_pls_golite062009
ribonucleotide binding 0.713752628021599 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.654899784430321 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.608058786636536 bayes_pls_golite062009
transcription factor activity 0.567932466447757 bayes_pls_golite062009
kinetochore binding 0.534490088080411 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
centromeric DNA binding 0.322818640526369 bayes_pls_golite062009
DNA helicase activity 0.29158988711192 bayes_pls_golite062009
ATP binding 0.19169045543599 bayes_pls_golite062009
helicase activity 0.17080683362659 bayes_pls_golite062009
adenyl ribonucleotide binding 0.165732470448462 bayes_pls_golite062009
adenyl nucleotide binding 0.162060759063149 bayes_pls_golite062009
dynein binding 0.150959629961177 bayes_pls_golite062009
active transmembrane transporter activity 0.114463153989353 bayes_pls_golite062009
microfilament motor activity 0.10236059675512 bayes_pls_golite062009
ion transmembrane transporter activity 0.081265446432119 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
recombinase activity 0.0490751527151101 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [174-481] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEYKKIAAQK TIEKKEAKLK EIKTILEEEI TPTIQKLKEE RSSYLEYQKV MREIEHLSRL  60
   61 YIAYQFLLAE DTKVRSAEEL KEMQDKVIKL QEELSENDKK IKALNHEIEE LEKRKDKETG 120
  121 GILRSLEDAL AEAQRVNTKS QSAFDLKKKN LACEESKRKE LEKNMVEDSK TLAAKEKEVK 180
  181 KITDGLHALQ EASNKDAEAL AAAQQHFNAV SAGLSSNEDG AEATLAGQMM ACKNDISKAQ 240
  241 TEAKQAQMKL KHAQQELKNK QAEVKKMDSG YRKDQEALEA VKRLKEKLEA EMKKLNYEEN 300
  301 KEESLLEK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.27
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #3
Region A:
Residues: [482-697] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRQLSRDIGR LKETYEALLA RFPNLRFAYK DPEKNWNRNC VKGLVASLIS VKDTSATTAL  60
   61 ELVAGERLYN VVVDTEVTGK KLLERGELKR RYTIIPLNKI SARCIAPETL RVAQNLVGPD 120
  121 NVHVALSLVE YKPELQKAME FVFGTTFVCD NMDNAKKVAF DKRIMTRTVT LGGDVFDPHG 180
  181 TLSGGARSQA ASILTKFQEL KDVQDELRIK ENELRA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.54
Match: 1gxlA
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.48985538444161 bayes_pls_golite062009
nucleic acid binding 1.85809295645854 bayes_pls_golite062009
DNA binding 1.71700314893388 bayes_pls_golite062009
protein binding 0.927138723776922 bayes_pls_golite062009
protein heterodimerization activity 0.558475595998159 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.299763949828861 bayes_pls_golite062009
DNA secondary structure binding 0.284996962785104 bayes_pls_golite062009
catalytic activity 0.265320175609019 bayes_pls_golite062009
pyrophosphatase activity 0.248383422632029 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.235472660839816 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.233111707634177 bayes_pls_golite062009
sequence-specific DNA binding 0.154578921841996 bayes_pls_golite062009
ATPase activity 0.08869715759545 bayes_pls_golite062009
protein dimerization activity 0.0245162068641336 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [698-1026] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEEELAGLKN TAEKYRQLKQ QWEMKTEEAD LLQTKLQQSS YHKQQEELDA LKKTIEESEE  60
   61 TLKNTKEIQR KAEEKYEVLE NKMKNAEAER ERELKDAQKK LDCAKTKADA SSKKMKEKQQ 120
  121 EVEAITLELE ELKREHTSYK QQLEAVNEAI KSYESQIEVM AAEVAKNKES VNKAQEEVTK 180
  181 QKEVITAQDT VIKAKYAEVA KHKEQNNDSQ LKIKELDHNI SKHKREAEDG AAKVSKMLKD 240
  241 YDWINAERHL FGQPNSAYDF KTNNPKEAGQ RLQKLQEMKE KLGRNVNMRA MNVLTEAEER 300
  301 YNDLMKKKRI VENDKSKILT TIEDLDQKK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.04
Match: 2oevA
Description: No description for 2oevA was found.

Predicted Domain #5
Region A:
Residues: [1027-1197] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQALNIAWQK VNKDFGSIFS TLLPGANAML APPEGQTVLD GLEFKVALGN TWKENLTELS  60
   61 GGQRSLVALS LILSMLLFKP APIYILDEVD AALDLSHTQN IGQMLRTHFT HSQFIVVSLK 120
  121 EGMFNNANVL FKTKFVDGVS TVARFTQCQN GKISKEAKSK AKPPKGAHVE V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1xewY
Description: Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle