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Protein Overview: HSP78_YEAST

General Information:
Name(s) found: HSP78_YEAST [Swiss-Prot]
Description(s) found:
  • Heat shock protein 78, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSP78 PE=1 SV=2 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 811 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRQATKAPI QKYLQRTQLL RRSTPRIYTI VQCKRSICSF NARPRVANKL LSDIKTNALN  60
   61 EVAISTCALK SSYGLPNFKR TYVQMRMDPN QQPEKPALEQ FGTNLTKLAR DGKLDPVIGR 120
  121 DEEIARAIQI LSRRTKNNPC LIGRAGVGKT ALIDGLAQRI VAGEVPDSLK DKDLVALDLG 180
  181 SLIAGAKYRG EFEERLKKVL EEIDKANGKV IVFIDEVHML LGLGKTDGSM DASNILKPKL 240
  241 ARGLRCISAT TLDEFKIIEK DPALSRRFQP ILLNEPSVSD TISILRGLKE RYEVHHGVRI 300
  301 TDTALVSAAV LSNRYITDRF LPDKAIDLVD EACAVLRLQH ESKPDEIQKL DRAIMKIQIE 360
  361 LESLKKETDP VSVERREALE KDLEMKNDEL NRLTKIWDAE RAEIESIKNA KANLEQARIE 420
  421 LEKCQREGDY TKASELRYSR IPDLEKKVAL SEKSKDGDKV NLLHDSVTSD DISKVVAKMT 480
  481 GIPTETVMKG DKDRLLYMEN SLKERVVGQD EAIAAISDAV RLQRAGLTSE KRPIASFMFL 540
  541 GPTGTGKTEL TKALAEFLFD DESNVIRFDM SEFQEKHTVS RLIGAPPGYV LSESGGQLTE 600
  601 AVRRKPYAVV LFDEFEKAHP DVSKLLLQVL DEGKLTDSLG HHVDFRNTII VMTSNIGQDI 660
  661 LLNDTKLGDD GKIDTATKNK VIEAMKRSYP PEFINRIDDI LVFNRLSKKV LRSIVDIRIA 720
  721 EIQDRLAEKR MKIDLTDEAK DWLTDKGYDQ LYGARPLNRL IHRQILNSMA TFLLKGQIRN 780
  781 GETVRVVVKD TKLVVLPNHE EGEVVEEEAE K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [92..286] PSI-BLAST 688.124002 ClpB
    3 View Details [287..425] ORFEUS 8.9 N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
    4 View Details [426..688] PSI-BLAST 7.522879 Replication factor C
    5 View Details [689..811] ORFEUS 12.61 HslU

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  3.04833973586251 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.97325763395103 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.88860382281825 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.82839518806942 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.62748401933955 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.55282098898104 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.5316131833172 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.53035702378505 bayes_pls_golite062009
  • binding
    		•  2.21604035604783 bayes_pls_golite062009
  • hydrolase activity
    		•  2.18454736627863 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  2.11085913752215 bayes_pls_golite062009
  • ATPase activity
    		•  2.04651885449197 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.87142752786895 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.61003954220885 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.52921795164482 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.35976511031033 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA binding
    		•  1.19966224604123 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.09075553688438 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.738234102557832 bayes_pls_golite062009
  • motor activity
    		•  0.70874549510465 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.640772201693186 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.63468044350616 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.62832939629645 bayes_pls_golite062009
  • GTP binding
    		•  0.621689261700018 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.613335848236039 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.314819889840159 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.226483101618176 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • transcription activator activity
    		•  0.129948034606198 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0612932659603008 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0558641287316701 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.050232896280066 bayes_pls_golite062009
  • helicase activity
    		•  0.0450969969658499 bayes_pls_golite062009
  • protein transporter activity
    		•  0.0071389922757723 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle