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View Structure Prediction Details

Protein: HSPA1B, HSPA1A
Organism: Homo sapiens
Length: 641 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSPA1B, HSPA1A.

Description E-value Query
Range		 Subject
Range
gi|68437749 - gi|68437749|ref|XP_699722.1| PREDICTED: similar to heat shock protein 70.2 [Danio rerio]
 0.0 [1..641] [82..722]
gi|25009896 - gi|25009896|gb|AAN71116.1| AT28834p [Drosophila melanogaster]
 0.0 [1..641] [40..680]
gi|67969126 - gi|67969126|dbj|BAE00917.1| unnamed protein product [Macaca fascicularis]
 0.0 [2..641] [4..641]
HS71L_MACFA - Heat shock 70 kDa protein 1-like OS=Macaca fascicularis GN=HSPA1L PE=2 SV=1
gi|109070526, gi... - gi|109070526|ref|XP_001113356.1| PREDICTED: similar to heat shock 70kDa protein 1-like isoform 3 [Ma...
 0.0 [2..641] [4..641]
HS71B_BOSMU - Heat shock 70 kDa protein 1B OS=Bos mutus grunniens GN=HSPA1B PE=2 SV=1
 0.0 [1..641] [1..641]
gi|57094365 - gi|57094365|ref|XP_532082.1| PREDICTED: similar to heat shock 70kDa protein 1-like isoform 1 [Canis ...
 0.0 [2..641] [4..641]
gi|3461866 - gi|3461866|dbj|BAA32521.1| heat shock protein 70 testis variant [Homo sapiens]
 0.0 [2..641] [4..641]

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Predicted Domain #1
Region A:
Residues: [1-561] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA  60
   61 LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK PKVQVSYKGD TKAFYPEEIS 120
  121 SMVLTKMKEI AEAYLGYPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA 180
  181 IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH 240
  241 FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA 300
  301 RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN 360
  361 KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI 420
  421 PTKQTQIFTT YSDNQPGVLI QVYEGERAMT KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI 480
  481 DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN 540
  541 ALESYAFNMK SAVEDEGLKG K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1yuwA
Description: crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 7.97191512372019 bayes_pls_golite062009
structural molecule activity 3.59589495899762 bayes_pls_golite062009
structural constituent of cytoskeleton 2.46121037473545 bayes_pls_golite062009
carbohydrate kinase activity 2.33338276303563 bayes_pls_golite062009
cytoskeletal protein binding 2.20983242331685 bayes_pls_golite062009
binding 2.11855816699924 bayes_pls_golite062009
protein binding 2.00711904074672 bayes_pls_golite062009
hydrolase activity 1.88613511243568 bayes_pls_golite062009
hexokinase activity 1.70516840340504 bayes_pls_golite062009
transcription regulator activity 1.68670098354938 bayes_pls_golite062009
nucleic acid binding 1.43834016708999 bayes_pls_golite062009
peptidase activity 1.4127499531612 bayes_pls_golite062009
DNA binding 1.36804228074586 bayes_pls_golite062009
transporter activity 1.2883466875237 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.16749728168925 bayes_pls_golite062009
kinase activity 1.11102445353265 bayes_pls_golite062009
actin binding 1.03829083423378 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.953663805249074 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.900931843471417 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.898645342556399 bayes_pls_golite062009
pyrophosphatase activity 0.875671218597808 bayes_pls_golite062009
substrate-specific transporter activity 0.796517590178929 bayes_pls_golite062009
transcription factor activity 0.783439770973386 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.78242344952806 bayes_pls_golite062009
protein transporter activity 0.780308299678282 bayes_pls_golite062009
ATPase activity 0.687771333492666 bayes_pls_golite062009
myosin binding 0.607451856096 bayes_pls_golite062009
glucose binding 0.53527958884988 bayes_pls_golite062009
glucokinase activity 0.47468456642723 bayes_pls_golite062009
catalytic activity 0.296484721581333 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.186218331473028 bayes_pls_golite062009
chromatin binding 0.155140608043269 bayes_pls_golite062009
protease binding 0.121259015422625 bayes_pls_golite062009
chaperone binding 0.00111313452804307 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [562-641] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISEADKKKVL DKCQEVISWL DANTLAEKDE FEHKRKELEQ VCNPIISGLY QGAGGPGPGG  60
   61 FGAQGPKGGS GSGPTIEEVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.09691
Match: 1dkyA
Description: DnaK
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle