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View Structure Prediction Details

Protein: MCM6
Organism: Saccharomyces cerevisiae
Length: 1017 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCM6.

Description E-value Query
Range
Subject
Range
MCM6_YEAST - DNA replication licensing factor MCM6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MC...
MCM6 - Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin ...
0.0 [1..1017] [1..1017]
gi|45199064, gi|... - gi|45199064|ref|NP_986093.1| AFR546Wp [Ashbya gossypii ATCC 10895], gi|44985139|gb|AAS53917.1| AFR54...
gi|44985139 - gi|44985139|gb|AAS53917.1| AFR546Wp [Ashbya gossypii ATCC 10895]
0.0 [4..1014] [9..1002]
gi|46111177, gi|... - gi|46111177|ref|XP_382646.1| hypothetical protein FG02470.1 [Gibberella zeae PH-1], gi|42547702|gb|E...
0.0 [6..1009] [78..1031]
gi|85106500 - gi|85106500|ref|XP_962193.1| hypothetical protein [Neurospora crassa OR74A]
gi|32408139, gi|... - gi|40882272|emb|CAF06096.1| probable replication licensing factor [Neurospora crassa], gi|32408139|r...
0.0 [17..1010] [1..972]
gi|68475306, gi|... - gi|68475507|ref|XP_718276.1| hypothetical protein CaO19.2611 [Candida albicans SC5314], gi|68475306|...
orf19.2611, orf1... - MCM6 CGDID:CAL0003376 Assembly 19, Contig19-10151 (137948, 140590) CDS, translated using codon table...
0.0 [16..1014] [4..880]
gi|71003694, gi|... - gi|71003694|ref|XP_756513.1| hypothetical protein UM00366.1 [Ustilago maydis 521], ref|XP_397981.1| ...
0.0 [1..1008] [1..971]
MCM6Z_XENTR - Zygotic DNA replication licensing factor mcm6 OS=Xenopus tropicalis GN=zmcm6 PE=2 SV=1
0.0 [159..1009] [1..823]
MCM6 - minichromosome maintenance complex component 6
0.0 [172..1009] [13..821]
gi|40746945, gi|... - gi|67515893|ref|XP_657832.1| hypothetical protein AN0228.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
0.0 [28..1010] [2..915]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPFPADTP SSNRPSNSSP PPSSIGAGFG SSSGLDSQIG SRLHFPSSSQ PHVSNSQTGP  60
   61 FVNDSTQFSS QRLQTDGSAT NDMEGNEPAR SFKSRALNHV KKVDDVTGEK VREAFEQFLE 120
  121 DFSVQSTDTG EVEKVYRAQI EFMKIYDLNT IYIDYQHLSM RE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [163-792]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGALAMAISE QYYRFLPFLQ KGLRRVVRKY APELLNTSDS LKRSEGDEGQ ADEDEQQDDD  60
   61 MNGSSLPRDS GSSAAPGNGT SAMATRSITT STSPEQTERV FQISFFNLPT VHRIRDIRSE 120
  121 KIGSLLSISG TVTRTSEVRP ELYKASFTCD MCRAIVDNVE QSFKYTEPTF CPNPSCENRA 180
  181 FWTLNVTRSR FLDWQKVRIQ ENANEIPTGS MPRTLDVILR GDSVERAKPG DRCKFTGVEI 240
  241 VVPDVTQLGL PGVKPSSTLD TRGISKTTEG LNSGVTGLRS LGVRDLTYKI SFLACHVISI 300
  301 GSNIGASSPD ANSNNRETEL QMAANLQANN VYQDNERDQE VFLNSLSSDE INELKEMVKD 360
  361 EHIYDKLVRS IAPAVFGHEA VKKGILLQML GGVHKSTVEG IKLRGDINIC VVGDPSTSKS 420
  421 QFLKYVVGFA PRSVYTSGKA SSAAGLTAAV VRDEEGGDYT IEAGALMLAD NGICCIDEFD 480
  481 KMDISDQVAI HEAMEQQTIS IAKAGIHATL NARTSILAAA NPVGGRYNRK LSLRGNLNMT 540
  541 APIMSRFDLF FVILDDCNEK IDTELASHIV DLHMKRDEAI EPPFSAEQLR RYIKYARTFK 600
  601 PILTKEARSY LVEKYKELRK DDAQGFSRSS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.09691
Match: 1qvrA_
Description: Crystal Structure Analysis of ClpB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 4.91429252297969 bayes_pls_golite062009
protein-DNA loading ATPase activity 4.80695929076807 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.66107861968804 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
DNA replication origin binding 1.62491387774159 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
microtubule motor activity 1.35938517416356 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
structure-specific DNA binding 1.20315703345493 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
kinase activity 1.11120928120082 bayes_pls_golite062009
double-stranded DNA binding 1.05408274676326 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.908046791062776 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.8469248456592 bayes_pls_golite062009
motor activity 0.61636596887462 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.421921195209539 bayes_pls_golite062009
single-stranded DNA binding 0.406600732518248 bayes_pls_golite062009
protein kinase activity 0.351308564667977 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
transferase activity 0.175269600441384 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.156278588350022 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
mismatched DNA binding 0.13366911641814 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
cytoskeletal protein binding 0.0272673919333979 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.0223627159838333 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [793-931]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRITVRQLES MIRLSEAIAR ANCVDEITPS FIAEAYDLLR QSIIRVDVDD VEMDEEFDNI  60
   61 ESQSHAASGN NDDNDDGTGS GVITSEPPAD IEEGQSEATA RPGTSEKKKT TVTYDKYVSM 120
  121 MNMIVRKIAE VDREGAEEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1um8A_
Description: Crystal structure of helicobacter pylori ClpX
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [932-1017]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAVDIVDWYL LQKENDLGSL AEYWEERRLA FKVIKRLVKD RILMEIHGTR HNLRDLENEE  60
   61 NENNKTVYVI HPNCEVLDQL EPQDSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle