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View Structure Prediction Details

Protein: C85A1_ARATH
Organism: Arabidopsis thaliana
Length: 465 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C85A1_ARATH.

Description E-value Query
Range
Subject
Range
CYP2C8 - cytochrome P450, family 2, subfamily C, polypeptide 8
364.0 [0..5] [464..1]

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Predicted Domain #1
Region A:
Residues: [1-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAMMVMMGL LLIIVSLCSA LLRWNQMRYT KNGLPPGTMG WPIFGETTEF LKQGPNFMRN  60
   61 QRLRYGSFFK SHLLGCPTLI SMDSEVNRYI LKNESKGLVP GYPQSMLDIL GTCNMAAVHG 120
  121 SSHRLMRGSL LSLISSTMMR DHILPKVDHF MRSYLDQWNE LEVIDIQDKT KHMAFLSSLT 180
  181 QIAGNLRKPF VEEFKTAFFK LVVGTLSVPI DLPGTNYRCG IQARNNIDRL LRELMQERRD 240
  241 SGETFTDMLG YLMKKEGNRY PLTDEEIRDQ VVTILYSGYE TVSTTSMMAL KYLHDHPKAL 300
  301 QELRAEHLAF RERKRQDEPL GLEDVKSMKF TRAVIYETSR LATIVNGVLR KTTRDLEING 360
  361 YLIPKGWRIY VYTREINYDA NLYEDPLIFN PWRWMKKSLE SQNSCFVFGG GTRLCPGKEL 420
  421 GIVEISSFLH YFVTRYRWEE IGGDELMVFP RVFAPKGFHL RISPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 97.69897
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
arachidonic acid monooxygenase activity 2.35162461983176 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1.97593187367475 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
oxygen binding 1.66120675703571 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 0.979631262400031 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.918503562996019 bayes_pls_golite062009
arachidonic acid epoxygenase activity 0.75181432044872 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.658520486133281 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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