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View Structure Prediction Details

Protein: MCM7_ARATH
Organism: Arabidopsis thaliana
Length: 716 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCM7_ARATH.

Description E-value Query
Range
Subject
Range
gi|675491 - gi|675491|gb|AAC37429.1| contains MCM2/3/5 family signature; PROSITE; PS00847; disruption leads to e...
573.0 [0..1] [716..1]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDHDFDGDK GLAKGFLENF ADANGRSKYM EILQEVSNRK IRAIQVDLDD LFNYKDESEE  60
   61 FLGRLTENTR RYVSIFSAAV DELLPEPTEA FPDDDHDILM TQRADDGTDN PDVSDPHQQI 120
  121 PSEIKRYYEV YFKAPSKGRP STIREVKASH IGQLVRISGI VTRCSD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.09691
Match: 1ltlA
Description: DNA replication initiator (cdc21/cdc54) N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [167-589]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKPLMAVAVY TCEDCGHEIY QEVTSRVFMP LFKCPSSRCR LNSKAGNPIL QLRASKFLKF  60
   61 QEAKMQELAE HVPKGHIPRS MTVHLRGELT RKVSPGDVVE FSGIFLPIPY TGFKALRAGL 120
  121 VADTYLEATS VTHFKKKYEE YEFQKDEEEQ IARLAEDGDI YNKLSRSLAP EIYGHEDIKK 180
  181 ALLLLLVGAP HRQLKDGMKI RGDVHICLMG DPGVAKSQLL KHIINVAPRG VYTTGKGSSG 240
  241 VGLTAAVMRD QVTNEMVLEG GALVLADMGI CAIDEFDKMD ESDRTAIHEV MEQQTVSIAK 300
  301 AGITTSLNAR TAVLAAANPA WGRYDLRRTP AENINLPPAL LSRFDLLWLI LDRADMDSDL 360
  361 ELAKHVLHVH QTEESPALGF EPLEPNILRA YISAARRLSP YVPAELEEYI ATAYSSIRQE 420
  421 EAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.30103
Match: 1ksfX
Description: N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 4.91429252297969 bayes_pls_golite062009
protein-DNA loading ATPase activity 4.80695929076807 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.66107861968804 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
microtubule motor activity 1.6537049553461 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
DNA replication origin binding 1.62491387774159 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
structure-specific DNA binding 1.20315703345493 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
double-stranded DNA binding 1.05408274676326 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.8469248456592 bayes_pls_golite062009
kinase activity 0.641541011250583 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.584453361662212 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
single-stranded DNA binding 0.406600732518248 bayes_pls_golite062009
protein kinase activity 0.351308564667977 bayes_pls_golite062009
histone acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.156278588350022 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
mismatched DNA binding 0.13366911641814 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific) 0.0642842984371965 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.0223627159838333 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [590-716]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNTPHSYTTV RTLLSILRIS AALARLRFSE SVAQSDVDEA LRLMQMSKIS LYADDRQKAG  60
   61 LDAISDTYSI IRDEAARSKK THVSYANALN WISRKGYSEA QLKECLEEYA ALNVWQIDPH 120
  121 TFDIRFI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.221849
Match: 2r44A
Description: No description for 2r44A was found.

YRC Informatics Platform - Version 3.0
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