YRC Public Data Repository - Protein Structure Prediction

Protein:	gcn5
Organism:	Schizosaccharomyces pombe
Length:	454 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gcn5.

Description	E-value	Query Range	Subject Range
gi\|55645415 - gi\|55645415\|ref\|XP_511500.1\| PREDICTED: similar to GCN5 general control of amino-acid synthesis 5-li... gi\|7428978, gi\|1... - pir\|\|S71789 GCN5 protein - human, gi\|1491935\|gb\|AAC50641.1\| histone acetyltransferase	473.0	[0..1]	[446..20]
gi\|114667307 - gi\|114667307\|ref\|XP_511500.2\| PREDICTED: GCN5 general control of amino-acid synthesis 5-like 2 isofo...	469.0	[0..1]	[446..381]
gi\|73965809 - gi\|73965809\|ref\|XP_860364.1\| PREDICTED: similar to GCN5 general control of amino-acid synthesis 5-li...	469.0	[0..1]	[446..128]
gi\|28516430, gi\|... - gi\|94376478\|ref\|XP_985227.1\| PREDICTED: similar to p300/CBP-associated factor [Mus musculus], gi\|285...	466.0	[0..4]	[446..376]
gi\|50733046 - gi\|50733046\|ref\|XP_426001.1\| PREDICTED: similar to PCAF [Gallus gallus]	466.0	[0..5]	[446..506]
gi\|149054242, gi... - gi\|157817171\|ref\|NP_001100520.1\| general control of amino acid synthesis 5-like 2 [Rattus norvegicus...	464.0	[0..1]	[446..376]

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Predicted Domain #1

Region A:
Residues: [1-103]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSLNDQTR PPDSSVVDST SSNFPNASND SVHDKPVKQD EQSNPNVREA IANSDGQESL  60
   61 AVKENKDTES SSSHFVPNGV SNSKKRKLVA TDLDVDFDIS SVR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [104-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTEKPSVLEE KSGVIQFRVV SNDDTADSMI MLTGLKNIFM KQLPKMPKEY ITRLIYDRNH  60
   61 LSMTIVKDNL HVVGGITYRP FEQRGFAEIV FCAIASNEQV R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.045757
Match:	1yghA
Description:	Catalytic domain of GCN5 histone acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [205-280]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYGSHLMNHL KDYVRGTTTI QHFLTYADNY AIGYFKKQGF TKEITLDKSI WVGYIKDYEG  60
   61 GTLMQCTMIP KIKYLE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.78
Match:	1yghA
Description:	Catalytic domain of GCN5 histone acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone acetyltransferase activity	9.77190406882468	bayes_pls_golite062009
lysine N-acetyltransferase activity	9.77190406882468	bayes_pls_golite062009
N-acetyltransferase activity	9.73964376866211	bayes_pls_golite062009
N-acyltransferase activity	9.60609829597779	bayes_pls_golite062009
acetyltransferase activity	8.97813893741415	bayes_pls_golite062009
acyltransferase activity	8.29975737946923	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	8.2593462862836	bayes_pls_golite062009
transferase activity, transferring acyl groups	8.04883596198777	bayes_pls_golite062009
	6.86025120243744	bayes_pls_golite062009
H3 histone acetyltransferase activity	5.83499424263076	bayes_pls_golite062009
	3.52813815101294	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	3.06288276492113	bayes_pls_golite062009
transferase activity	2.55875279009494	bayes_pls_golite062009
transcription regulator activity	2.26346740872821	bayes_pls_golite062009
nucleic acid binding	2.14720849412601	bayes_pls_golite062009
catalytic activity	1.823104805379	bayes_pls_golite062009
binding	1.30356860355657	bayes_pls_golite062009
transcription coactivator activity	1.05620338082006	bayes_pls_golite062009
transcription factor binding	0.999468823887739	bayes_pls_golite062009
transcription activator activity	0.800725992277502	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.60912193595326	bayes_pls_golite062009
histone binding	0.511669465942587	bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity	0.333301232703043	bayes_pls_golite062009
myristoyltransferase activity	0.333301232703043	bayes_pls_golite062009
transcription cofactor activity	0.207688916644661	bayes_pls_golite062009
protein binding	0.116359302536336	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [281-454]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANLILAIQKA AVVSKINRIT RSNVVYPGLD VFKDGPAHIE PSQVPGLMEV GWCKEMEELS  60
   61 KKPRPKPFFA VLEMLFTEMQ NHPSSWPFMQ PVSKEDVPDY YEVIEHPMDL STMEFRLRNN 120
  121 QYESVEEFIR DAKYIFDNCR SYNDSNTTYY KNADRLEKFF QKKLRETEYS HLAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.0
Match:	1e6iA
Description:	GCN5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone acetyltransferase activity	9.91927576220387	bayes_pls_golite062009
lysine N-acetyltransferase activity	9.91927576220387	bayes_pls_golite062009
N-acetyltransferase activity	7.57346092874507	bayes_pls_golite062009
N-acyltransferase activity	7.12398761720889	bayes_pls_golite062009
acetyltransferase activity	6.51488433263281	bayes_pls_golite062009
acyltransferase activity	5.44980261163837	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	5.38368530556466	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	5.26899007107713	bayes_pls_golite062009
transferase activity, transferring acyl groups	5.06705016462047	bayes_pls_golite062009
	4.94702795409425	bayes_pls_golite062009
transcription regulator activity	3.81944587687526	bayes_pls_golite062009
DNA binding	3.34863990009219	bayes_pls_golite062009
nucleic acid binding	3.25178464591722	bayes_pls_golite062009
binding	3.24233563871512	bayes_pls_golite062009
histone binding	2.93206976627622	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.58609800997327	bayes_pls_golite062009
transcription coactivator activity	2.37993162280856	bayes_pls_golite062009
transcription factor binding	2.33866683789609	bayes_pls_golite062009
transcription activator activity	1.99519727421308	bayes_pls_golite062009
MyoD binding	1.89625280750577	bayes_pls_golite062009
MRF binding	1.89625280750577	bayes_pls_golite062009
chromatin binding	1.85568770971367	bayes_pls_golite062009
protein binding	1.82955314054861	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.82747962293997	bayes_pls_golite062009
protein kinase activity	1.63512839295568	bayes_pls_golite062009
transcription cofactor activity	1.60584871002187	bayes_pls_golite062009
transcription factor activity	1.30026489619787	bayes_pls_golite062009
DNA-dependent ATPase activity	1.28824771134976	bayes_pls_golite062009
protein serine/threonine kinase activity	1.15145628425168	bayes_pls_golite062009
sequence-specific DNA binding	1.08961199627679	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.07760436003896	bayes_pls_golite062009
transcription initiation factor activity	0.96034823197127	bayes_pls_golite062009
kinase activity	0.890638513095454	bayes_pls_golite062009
peroxisome proliferator activated receptor binding	0.547697825358481	bayes_pls_golite062009
structural molecule activity	0.398844600914114	bayes_pls_golite062009
transferase activity	0.321534577277088	bayes_pls_golite062009
RNA polymerase binding	0.29341314806541	bayes_pls_golite062009
transcription repressor activity	0.0167144924052265	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: